BIOACTIVE COATING FOR MEDICAL DEVICES
A medical device (and method for making same) comprising a passivating coating comprising keratin.
1 .- 33 . (canceled)
34 . A medical implant comprising:
a substrate comprising a passivating coating comprising keratin, said passivating coating being effective to increase bone matrix formation by cultured 2T3 mouse osteoblasts, said passivating coating comprising a bonding region and a bioactive region;
said bonding region comprising at least one organosilane compound comprising a silane component bound to a surface of said substrate; and
said bioactive region comprising an organic component of said organosilane bound to a reactive pendant group on said keratin.
35 . The medical implant of claim 34 wherein said silane component of said organosilane compound is covalently bonded with a surface of the substrate.
36 . The medical implant of claim 34 wherein said bioactive region comprises reactive pendant groups on said keratin covalently bonded to said organic component of said organosilane.
37 . (canceled)
38 . The medical implant of claim 34 wherein said passivating coating comprises keratin and one or more bioactive factors selected from bone morphogenetic protein and transforming growth factor beta.
39 - 41 . (canceled)
42 . The medical implant of claim 34 wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, amine groups, isocyanate groups, and carboxyl groups.
43 . (canceled)
44 . The medical implant of claim 42 wherein said amine groups are alkylamine groups.
45 . The medical implant of claim 34 wherein said organic component comprises a moiety selected from the group consisting of vinyl groups and epoxy groups.
46 - 57 . (canceled)
58 . The medical implant of claim 34 wherein said organosilane comprises substituents selected from 1 to 3 halogens and 1 to 3 alkoxy groups.
59 - 70 . (canceled)
71 . The medical implant of claim 34 wherein said keratin comprises keratin having a molecular weight of from about 50 to about 85 kDa.
72 - 160 . (canceled)
161 . A medical implant comprising:
a substrate comprising a passivating coating comprising keratin, said passivating coating comprising a bonding region and a bioactive region;
said bonding region comprising at least one organosilane compound comprising a silane component bound to a surface of said substrate; and
said bioactive region comprising an organic component of said organosilane bound to a reactive pendant group on said keratin.
162 . The medical implant of claim 161 wherein said silane component of said organosilane compound is covalently bonded with a surface of the substrate.
163 . The medical implant of claim 161 wherein said bioactive region comprises reactive pendant groups on said keratin covalently bonded to said organic component of said organosilane.
164 . (canceled)
165 . The medical implant of claim 161 wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, amine groups, isocyanate groups, and carboxyl groups.
166 . (canceled)
167 . The medical implant of claim 165 wherein said amine groups are alkylamine groups.
168 . The medical implant of claim 161 wherein said organic component comprises a moiety selected from the group consisting of vinyl groups and epoxy groups.
169 . The medical implant of claim 163 wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, amine groups, isocyanate groups, and carboxyl groups.
170 . The medical implant of claim 163 wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, and amine groups.
171 . The medical implant of claim 170 wherein said amine groups are alkylamine groups.
172 .- 176 . (canceled)
177 . The medical implant of claim 161 wherein said organosilane comprises substituents are selected from 1 to 3 halogens and 1 to 3 alkoxy groups.
178 - 185 . (canceled)
186 . The medical implant of claim 161 wherein said keratin comprises keratin having a molecular weight of from about 50 to about 85 kDa.
187 - 199 . (canceled)
200 . The medical implant of claim 161 wherein the substrate comprises one or more biocompatible material is selected from the group consisting of silicon, metals, metal alloys, and ceramics.
201 . The medical implant of claim 161 wherein said biocompatible material is selected from the group consisting of titanium and hydroxyapatite.
202 . The medical implant of claim 161 wherein said biocompatible material comprises silicon.
203 - 220 . (canceled)
221 . An orthopedic medical implant comprising:
a substrate comprising a passivating coating comprising keratin, said passivating coating comprising a bonding region and a bioactive region;
said bonding region comprising at least one organosilane compound comprising a silane component covalently bound to a surface of said substrate; and
said bioactive region comprising an organic component of said organosilane bound to a reactive pendant group on said keratin.
222 . The orthopedic implant of claim 221 wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, amine groups, isocyanate groups, and carboxyl groups.
223 . The orthopedic implant of claim 222 wherein said amine groups are alkylamine groups.
224 . The orthopedic implant of claim 221 wherein said organic component comprises a moiety selected from the group consisting of vinyl groups and epoxy groups.
225 . The medical implant of claim 221 wherein said organic component of said organosilane comprises a moiety selected from the group consisting of epoxy groups, alkoxy groups, vinyl groups, and amine groups.
226 . The medical implant of claim 227 wherein said amine groups are alkylamine groups.
227 . The medical implant of claim 221 wherein said organosilane comprises substituents are selected from 1 to 3 halogens and 1 to 3 alkoxy groups.
228 . The medical implant of claim 221 wherein said keratin comprises keratin having a molecular weight of from about 50 to about 85 kDa.
229 . The medical implant of claim 221 wherein the substrate comprises one or more biocompatible material is selected from the group consisting of silicon, metals, metal alloys, and ceramics.
230 . The medical implant of claim 221 wherein said biocompatible material is selected from the group consisting of titanium and hydroxyapatite.
231 . The medical implant of claim 221 wherein said biocompatible material comprises silicon.