Process for the production of collagen material
The invention relates to a process for the production of a collagen implant for wound covering, in which a suspension comprising a telopeptide-containing collagen is produced and a phosphate buffer is added. An areal structure is produced by drying the collagen-containing mixture produced.
1. A process for the production of a collagen material, comprising:
(a) producing an suspension comprising a telopeptide-containing collagen wherein said suspension has an acidic pH which has been adjusted by the addition of phosphoric acid;
(b) adding a phosphate buffer to the suspension of step (b), resulting in a telopeptide collagen-containing mixture; and
(c) drying the telopeptide collagen-containing mixture, thereby producing an areal structure.
2. The process of claim 1 , wherein a native collagen is used to produce the suspension.
3. The process of claim 1 , wherein mammalian skins are used as the collagen material.
4. The process of claim 1 , wherein the collagen-containing mixture is adjusted to a pH between 5.5 and 8.5 by addition of the phosphate buffer.
5. The process of claim 1 , wherein the suspension is produced with a collagen content of 0.3-7 wt %.
6. The process of claim 1 , wherein before drying, the mixture is adjusted to have a solids content of 0.2-10%.
7. The process of claim 1 , wherein the areal structure is produced with a disodium hydrogen phosphate component of 80-500 mg/g.
8. The process for the production of a collagen material in accordance with claim 1 , wherein the suspension of step (a) is mechanically denatured.
9. The process of claim 1 , further comprising adding an antibiotic.
10. The process of claim 3 , wherein mammalian skins from pigs are used as the collagen material.