IP Library › Granted Patent US 10,077,428
Granted Patent B2
US 10,077,428 · App. 12/410,782 · Granted Sep 18, 2018

Human cardiovascular progenitor cells

Inventors: Gordon Keller (Toronto, CA); Lei Yang (New York, NY); Steven Kattman (Toronto, CA)
Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
C12N5/0657A61K35/12C12N2501/115C12N2501/155C12N2501/16C12N2501/165C12N2501/415C12N2506/02
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,077,428
App. No.
12/410,782
Granted
Sep 18, 2018
Kind
B2
Abstract

The present invention provides populations of human cardiovascular progenitor cells, methods of making such cells, and methods of using the cells for production of populations of cardiovascular colonies and populations of cardiomyocytes. Methods of cardiomyocytes replacement therapy are also provided.

Claims (5)

1. An isolated population of human cardiovascular progenitor cells derived from human pluripotent stem cells in vitro, wherein the progenitor cells express KDR and do not express C-KIT and VE-CADHERIN and wherein the progenitor cells are progenitors of cardiomyocytes, endothelial cells, and vascular smooth muscle cells.

2. The population of human cardiovascular progenitor cells of claim 1 obtained by culturing human embryoid bodies in serum free media in the presence of activin and BMP.

3. The population of claim 2 wherein activin is activin A.

4. The population of claim 2 wherein BMP is BMP4.

5. A composition comprising the isolated population of human cardiovascular progenitor cells of claim 1 .

Assignments (2)
CHANGE OF NAME Recorded Nov 13, 2015
From: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
To: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
Reel/Frame 037109/0799 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2009
From: KELLER, GORDON M.; YANG, LEI; KATTMAN, STEVEN
To: MOUNT SINAI SCHOOL OF MEDICINE OF NEW YORK UNIVERSITY
Reel/Frame 022883/0218 →
Continuity (2)
Provisional Application 61040049 · Mar 27, 2008
Related Publication 20090269314A1 · Oct 29, 2009