Granted Patent
B2
US 9,005,643 · App. 12/417,981 · Granted Apr 14, 2015
Inhibition of bacterial biofilms with imidazole-phenyl derivatives
Inventors:
Christian Melander (Raleigh, NC); Justin J. Richards (Durham, NC); Cynthia Bunders (Raleigh, NC)
Assignee:
North Carolina State University
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Abstract
Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
Claims (10)
1. A composition comprising a compound of Formula (I)(a):
wherein:
R 1 is C5 or C6 alkyl;
R 1′ , R 2 and R 2′ are each H; and
n=0;
or a pharmaceutically acceptable salt thereof
and a carbapenem antibiotic.
2. The composition of claim 1 , wherein R 1 is C6 alkyl.
3. The composition of claim 1 , wherein said compound of Formula (I)(a) has the formula:
or a pharmaceutically acceptable salt thereof.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 13, 2009
From: MELANDER, CHRISTIAN; RICHARDS, JUSTIN J.; BUNDERS, CYNTHIA
To: NORTH CAROLINA STATE UNIVERSITY
Reel/Frame 022946/0606 →
Continuity (2)
Provisional Application
61042473
· Apr 4, 2008