IP Library › Granted Patent US 8,148,146
Granted Patent B2
US 8,148,146 · App. 12/418,062 · Granted Apr 3, 2012

Cell line

Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
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Quick Facts
Patent No.
US 8,148,146
App. No.
12/418,062
Granted
Apr 3, 2012
Kind
B2
Abstract

The invention provides a cell line complementing HSV ICP4, ICP27, and UL55 genes.

Claims (3)

1. A cell line that contains herpes simplex virus (HSV) ICP4, ICP27, and UL55 genes, wherein the cell line supports the replication of an HSV vector comprising deletions in ICP4, ICP27, and UL55 genes, wherein the vector does not comprise a deletion in UL56.

2. A combination comprising the cell of claim 1 and an HSV vector comprising deletions in ICP4, ICP27, and UL55 genes, wherein the ICP4, ICP27, and UL55 genes within the cell share no homology with the vector DNA.

3. The combination of claim 2 , wherein the vector comprises a transgene.

Assignments (2)
CONFIRMATORY LICENSE Recorded Jun 8, 2016
From: UNIVERSITY OF PITTSBURGH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 038906/0049 →
CONFIRMATORY LICENSE Recorded Mar 27, 2014
From: UNIVERSITY OF PITTSBURGH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 032540/0558 →
Continuity (5)
Division 11694118 · Mar 30, 2007
Division 11261389 · Oct 28, 2005
Continuation PCTUS2005039162 · Oct 28, 2005
Provisional Application 60622889 · Oct 28, 2004
Related Publication 20090238807A1 · Sep 24, 2009