IP Library Patent Application 12419978
Patent Application
App. No. 12/419,978

METHOD AND APPARATUS FOR FORENSIC SCREENING

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Quick Facts
Patent No.
US None
App. No.
12/419,978
Abstract

This invention relates to methods and system for forensic screening. More specifically, this invention relates to various methods to detect or screen for at least one designated genetic sequences in a plurality of biological sample 40 using a template 30 in conjunction with a laboratory management software 24 to automatically control a workstation and to automatically rescreen samples 40 to achieve a high level of accuracy while tracking the samples 40 for chain of custody purposes.

Claims (28)

1 . A computer implemented method for processing physical crime data by a vendor laboratory for a user comprising the steps of:

receiving data to populate a template in a laboratory information management system;

receiving a transportation package identifier in computer readable form for biological samples sent by said user to said vendor laboratory;

receiving a sample identifier in computer readable form for said samples;

receiving at least one genetic sequence in computer readable form for said samples;

storing the transportation package identifier, sample identifier and at least one genetic sequence in computer readable form in the laboratory information management system in association with a template;

receiving at said vendor laboratory said samples having said transportation package identifier in computer readable form;

screening said samples in a workstation automatically directed by said template while recording said sample identifier at each step of the screening to generate physical data;

identifying at least one nonconforming sample by comparing physical data to said template;

generating a work list by said laboratory management system to rescreen said at least one nonconforming sample; and

rescreening said at least one nonconforming sample in said workstation according to the work list while recording said sample identifier at each step of the screening to generate new physical data; said workstation being communicatively coupled to said laboratory information management system.

2 . The method of claim 1 further comprising the steps of:

generating electronic representations of said physical data; and

transmitting said electronic representations associated with said sample identifier to said user.

3 . The method of claim 1 , wherein said samples are disposed in a tube, further comprising the steps of: receiving an identifier for a tube for a biological sample and storing said tube identifier in said laboratory information management system in association with said sample identifier.

4 . The method of claim 1 , wherein said sample are disposed in a well of a multi-well container, further comprising the steps of: acquiring an identifier for a multi-well plate and a position of a sample in a well of a multi-well plate and storing said well plate position is said laboratory information management system in association with said sample identifier.

5 . The method of claim 1 further comprising: conducting a presumptive test to associate the source of said samples to provide presumptive data and storing the presumptive data in said laboratory information management system in association with said sample identifier.

6 . The method of claim 1 wherein said template is generated by populating said laboratory information management system with parameters selected from the group consisting of: a unique identifier generated by said user, types of samples, sample medium, and numbers of samples.

7 . The method of claim 1 wherein said template is generated by populating said laboratory information management system with parameters selected from the group consisting of: STR kit type, electrophoresis platform, raw peak height, peak height ratio cut off, stutter ratio cut off, negative adenylation cut off (−A), and percent shoulder cut off.

8 . The method of claim 1 wherein said template is generated by populating said laboratory information management system with parameters selected from the group consisting of: standard operating procedure to process tri-alleles and off ladder alleles, standard operation procedure on spiking and enriching, control sample order, and reaction volume.

9 . The method of claim 1 wherein said template is generated by populating said laboratory information management system with parameters comprising blood card punches per samples associated with said sample identifier.

10 . The method of claim 1 wherein said template is generated by populating said laboratory information management system with parameters selected from the group consisting of: amount of time that the user anticipates sending said samples; time allotted to screen said samples; how many samples are to be released on a specific timeline; standard operation procedure on composite profiling; and return and destruction standard operation procedure for said samples.

11 . The method of claim 1 wherein said template is generated by populating said laboratory information management system with parameters selected from the group consisting of: standard operation procedure to isolate DNA, standard operating procedure to amplify DNA; how much of the sample can used for screening said samples; and internal lane standard sizing range.

12 . The method of claim 1 further comprising comparing said data to a negative control.

13 . The method of claim 1 further comprising comparing said data to a positive control.

14 . The method of claim 1 further comprising the step of adding a first lysis reagent to a first portion of said samples associated with said sample identifier and a second lysis reagent to a second portion of said samples associated with said sample identifier.

15 . An analysis laboratory with a device for receiving electronic data from a sender laboratory which is at a location which is physically separate from the analysis laboratory, with a device for receiving a physical sample which corresponds to the electronic data, the analysis laboratory comprising a template in a laboratory information management system and process controller 26 device which uses at least part of the received electronic data for automatically controlling the handling of the samples by operating units of a workstation device, the analysis laboratory further generating measurement data by evaluating the physical samples in at least one operating unit of the workstation device said laboratory information management system configured to identify data nonconforming to the template and signal the process controller for a specific portion of the workstation device to generate new measurement data, and outputting the new measurement data.

16 . The analysis laboratory of claim 15 further comprising a lysis station configured for differential extraction of genetic material.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Apr 10, 2018
From: LANDMARK COMMUNITY BANK
To: TRANSNETYX, INC.
Reel/Frame 045496/0474 →
RELEASE OF SECURITY INTEREST Recorded Apr 10, 2018
From: PENINSULA FUND V LIMITED PARTNERSHIP
To: TRANSNETYX, INC.
Reel/Frame 045496/0775 →
SECURITY INTEREST Recorded Apr 30, 2015
From: TRANSNETYX, INC.
To: THE PENINSULA FUND V LIMITED PARTNERSHIP
Reel/Frame 035539/0054 →
SECURITY INTEREST Recorded May 29, 2014
From: TRANSNETYX
To: LANDMARK COMMUNITY BANK
Reel/Frame 033053/0834 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 16, 2012
From: HODGE, TIMOTHY A.
To: TRANSNETYX, INC.
Reel/Frame 028797/0059 →