Borosilicate glass with UV-blocking properties for pharmaceutical packaging
The borosilicate glass for pharmaceutical packaging has a transmission τ in the visible range of more than 80% at a wavelength of 400 nm, a transmission τ in the UV range of at most 0.1% at wavelengths under 260 nm (each at a sample thickness of 1 mm), a transformation temperature Tg of 550° C. to 590° C. and a processing temperature V A of 1100° C. to 1200° C. The glass has a composition, in wt. % on an oxide basis, of SiO 2 , 60-80; B 2 O 3 , 5-15; Al 2 O 3 , 2-10; TiO 2 , 0.5-7; Σ Li 2 O+K 2 O+Na 2 O, 3-10; Σ alkaline earth oxides, 0.5-10; ZrO 2 , 0-3; and Fe 2 O 3 , 0-0.2. The glass is suitable for packaging UV-sensitive substances but nevertheless permits optical quality control.
1. A borosilicate glass with UV-blocking properties for pharmaceutical packaging, said borosilicate glass comprising, in wt. % on the basis of oxide content:
SiO 2
60-80
B 2 O 3
8.2-15
Al 2 O 3
2-10
TiO 2
0.5-7
Σ Li 2 O + K 2 O + Na 2 O
3-10
Σ alkaline earth oxides
0.5-10
ZrO 2
0-3
Fe 2 O 3
0-0.2;
and a glass transition temperature Tg of 550° C. to 590° C., a processing temperature V A of 1100° C. to 1200° C. at a viscosity of 10 4 Pa s, a transmission π of at least 80% at a wavelength of 400 nm, and a transmission π of less than 0.1% at a wavelength of under 260 nm, each for a sample thickness of 1 mm, and
wherein the borosilicate glass is made by melting under oxidizing conditions.
2. The borosilicate glass as defined in claim 1 , containing from 0.5 to 5.5 wt. % of TiO 2 .
3. The borosilicate glass as defined in claim 1 , containing from 50 ppm to 1500 ppm of Fe 2 O 3 .
4. The borosilicate glass as defined in claim 1 , in which at least 80% of the TiO 2 present is in the +4 oxidation state.
5. The borosilicate glass as defined in claim 1 , which is refined with As 2 O 3 and/or Sb 2 O 3 as refining agent.
6. The borosilicate glass as defined in claim 1 , further comprising up to 1 wt. % of F.
7. The borosilicate glass as defined in claim 1 , wherein Fe 2 O 3 is present and a molar ratio of Fe 2 O 3 to TiO 2 is greater than ⅙.
8. The borosilicate glass as defined in claim 1 , further comprising from 0 to 3 wt. % of Bi 2 O 3 , 0 to 1 wt. % of WO 3 , and from 0 to 1 wt. % of MoO 3 .
9. A borosilicate glass with UV-blocking properties for pharmaceutical packaging, said borosilicate glass comprising in wt. %:
SiO 2
69-77
B 2 O 3
10-12
Al 2 O 3
3.5-6
TiO 2
0.1-7
Na 2 O
6-8
CaO
1-2.5
Σ Li 2 O + K 2 O + Na 2 O
3-10
Σ alkaline earth oxides
0.5-10
ZrO 2
0-1
F
0.20-1
Fe 2 O 3
0-1500 ppm;
and a glass transition temperature Tg of 550° C. to 590° C., a processing temperature V A of 1100° C. to 1200° C. at a viscosity of 10 4 Pa s, a transmission π of at least 80% at a wavelength of 400 nm, and a transmission π of less than 0.1% at a wavelength of under 260 nm, each for a sample thickness of 1 mm, and
wherein the borosilicate glass is made by melting under oxidizing conditions.
10. The borosilicate glass as defined in claim 1 , containing, in wt. %:
SiO 2
67-75
B 2 O 3
8.2-10
Al 2 O 3
3-7
TiO 2
0.5-4.5
Na 2 O
5.5-8
CaO
0.5-2
BaO
1-3
ZrO 2
0-1
F
0.20-1
Fe 2 O 3
50 ppm-1500 ppm.
11. A pharmaceutical package for a pharmaceutical preparation, said pharmaceutical package comprising a borosilicate glass with UV-blocking properties for pharmaceutical packaging, said borosilicate glass comprising, in wt. % on the basis of oxide content:
SiO 2
60-80
B 2 O 3
8.2-15
Al 2 O 3
2-10
TiO 2
0.5-7
Σ Li 2 O + K 2 O + Na 2 O
3-10
Σ alkaline earth oxides
0.5-10
ZrO 2
0-3
Fe 2 O 3
0-0.2;
and a glass transition Tg of 550° C. to 590° C., a processing temperature V A of 1100° C. to 1200° C. at a viscosity of 10 4 Pa s, a transmission π of at least 80% at a wavelength of 400 nm, and a transmission π of less than 0.1% at a wavelength of under 260 nm, each for a sample thickness of 1 mm, and
wherein the borosilicate glass is made by melting under oxidizing conditions.
12. The pharmaceutical package as defined in claim 11 , wherein said borosilicate glass contains from 0.5 to 4.5 wt. % of TiO 2 and from 50 ppm to 1500 ppm of Fe 2 O 3 .