Substituted pyrimidinones

1. A method of treating neuropathic pain in a subject, the method comprising treating a subject in need thereof with a therapeutically effective amount of a compound of the formula

or a pharmaceutically acceptable salt thereof, wherein

L is —O—;

M is —CH 2 —;

R 5 is

 wherein

X 1 , X 2 , X a , X b , X c , X d , and X e at are independently selected from —C(O)NR 6 R 7 , —(C 1 -C 4 alkyl)-C(O)NR 6 R 7 , —NR 6 R 7 , hydroxy(C 1 -C 4 )alkyl, C 1 -C 4 dihydroxyalkyl, H, halogen, haloalkyl, alkyl, haloalkoxy, heteroaryl, heterocycloalkyl, C 3 -C 7 , cycloalkyl, R 6 R 7 N—(C 1 -C 6 alkyl)-, —CO 2 —(C 1 -C 6 ) alkyl, —N(R)C(O)NR 6 R 7 , —N(R)C(O)—(C 1 -C 6 )alkoxy, CO 2 R—(C 1 -C 6 alkyl)-, or —SO 2 NR 6 R 7 ; wherein the heteroaryl and heterocycloalkyl groups are optionally substituted with —NR 6 R 7 , —C(O)NR 6 R 7 , R 6 R 7 N—(C 1 -C 6 alkyl)-, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, or halogen; or

R 5 is heteroaryl or heteroarylalkyl, wherein the heteroaryl and heteroaryl groups are optionally substituted with 1, 2, 3, or 4 groups that are independently —C(O)NR 6 R 7 , —(C 1 -C 4 alkyl)-C (O)NR 6 R 7 , —NR 6 R 7 , hydroxy(C 1 -C 4 )alkyl, C 1 -C 4 dihydroxyalkyl, H, OH, halogen, haloalkyl, alkyl, haloalkoxy, R 6 R 7 N—(C 1 -C 6 alkyl)-, —CO 2 —(C 1 -C 6 )alkyl, —N(R)C(O)NR 6 R 7 , or —N(R)C(O)—(C 1 -C 6 ) alkoxy; wherein

R 6 and R 7 are independently at each occurrence H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxy C 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonyl, OH, C 1 -C 6 hydroxyalkyl, C 1 -C 4 dihydroxyalkyl, C 1 -C 6 thiohydroxyalkyl, —C 1 -C 4 )alkyl-CO 2 -alkyl, pyridyl C 1 -C 6 alkyl, C 1 -C 6 alkanoyl, benzyl, phenyl C 1 -C 6 alkoxy, or phenyl C 1 -C 6 alkanoyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently, halogen, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, piperidinyl C 1 -C 6 alkyl, morpholinyl C 1 -C 6 alkyl, piperazinyl C 1 -C 6 alkyl, OH, SH, NH 2 , NH(alkyl), N(alkyl)(alkyl), —O—C 1 -C 4 alkanoyl, C 1 -C 4 alkyl, CF 3 , or OCF 3 ; or

R 6 , R 7 , and the nitrogen to which they are attached form a morpholinyl, thiomorpholinyl, piperidinyl, pyrrolidinyl, or piperazinyl ring which is optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, hydroxy, hydroxy C 1 -C 4 alkyl, C 1 -C 4 dihydroxyalkyl, or halogen;

R at each occurrence is independently H or C 1 -C 6 alkyl; and

Y, Y 1 , Y 2 , Y 3 , and Y 4 are independently selected from H, halogen, alkyl, carboxaldehyde, hydroxyalkyl, dihydroxyalkyl, alkenyl, alkynyl, CN, alkanoyl, alkoxy, alkoxyalkyl, haloalkyl, and carboxyl.

2. A method according to claim 1 , wherein

3. The method according to claim 2 , wherein

X a is hydrogen;

two of X b , X c , and X d are hydrogen and the other is —C(O)NR 6 R 7 , —(C 1 -C 4 alkyl)-C (O)NR 6 R 7 , —NR 6 R 7 , R 6 R 7 N—(C 1 -C 6 alkyl)- or —CO 2 —(C 1 -C 6 )alkyl; wherein

R 6 and R 7 are independently at each occurrence H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxy C 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonyl, OH, C 1 -C 6 hydroxyalkyl, C 1 -C 4 dihydroxyalkyl, -(C 1 -C 4 )alkyl-CO 2 -alkyl, pyridyl C 1 -C 6 alkyl, C 1 -C 6 alkanoyl, benzyl, phenyl C 1 -C 6 alkoxy, or phenyl C 1 -C 6 alkanoyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently, halogen, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, piperidinyl C 1 -C 6 alkyl, morpholinyl C 1 -C 6 alkyl, piperazinyl C 1 -C 6 alkyl, OH, NH 2 , NH(alkyl), N(alkyl)(alkyl), —O—C 1 -C 4 alkanoyl, C 1 -C 4 alkyl, CF 3 , or OCF 3 ; or

R 6 , R 7 , and the nitrogen to which they are attached form a morpholinyl, piperidinyl, pyrrolidinyl, or piperazinyl ring which is optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, hydroxy, hydroxy C 1 -C 4 alkyl, C 1 -C 4 dihydroxyalkyl, or halogen; and

X e is hydrogen, methyl, C 1 -C 2 alkoxy, or halogen.

4. The method according to claim 3 , wherein

X b is —C(O)NR 6 R 7 , —(C 1 -C 4 alkyl)-C(O)NR 6 R 7 , —NR 6 R 7 , or R 6 R 7 N—(C 1 -C 6 alkyl)- wherein

R 6 is hydrogen or C 1 -C 4 alkyl;

R 7 is OH, C 1 -C 6 alkyl or C 1 -C 6 alkanoyl, wherein the alkyl and alkanoyl groups are substituted with 1, 2, or 3 groups that are independently NH 2 , NH(C 1 -C 6 alkyl), N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), C 3 -C 6 cycloalkyl, OH, or C 1 -C 4 alkoxy.

5. The method according to claim 2 , wherein

X a is halogen or methyl;

X b is H, —NR 6 R 7 , R 6 R 7 N—(C 1 -C 6 alkyl)-, —C(O)NR 6 R 7 , or —CO 2 —(C 1 -C 6 )alkyl;

X c is —NR 6 R 7 , R 6 R 7 N—(C 1 -C 6 alkyl)-, —C(O)NR 6 R 7 , halogen, —CO 2 —(C 1 -C 6 )alkyl, NH 2 , NH(C 1 -C 6 alkyl), N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1 -C 6 alkyl), —SO 2 N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl), or piperazinyl, wherein the piperazinyl group is optionally substituted with 1 or 2 groups that are independently C 1 -C 4 alkyl, C 1 -C 4 alkoxy, or halogen;

X d is hydrogen; and

X e is H, methyl, NH 2 , NH(C 1 -C 6 alkyl) or N(C 1 -C 6 alkyl)(C 1 -C 6 alkyl).

6. The method according to claim 2 , wherein

X 1 , X 2 , X a , X b , X c , X d , and X e are independently selected from H, halogen, CF 3 , alkyl, OCF 3 , pyridyl, pyridazinyl, pyrimidyl, pyrazinyl, thienyl, furyl, pyrrolyl, piperidinyl, piperazinyl, or C 3 -C 7 cycloalkyl, wherein any heteroaryl or the heterocycloalkyl group is optionally substituted with —NR 6 R 7 , —C(O)NR 6 R 7 , R 6 R 7 N—(C 1 -C 6 alkyl)-, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, or halogen.

7. The method according to claim 1 , wherein

R 5 is a heteroaryl or heteroarylalkyl group, where each heteroaryl is pyrazolyl, imidazolyl, furanyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrazolyl, imidazolyl, dihydroindolyl, dihydroisoindolyl, indolon-2-yl, quinolinyl, isoquinolinyl, tetrahydroisoquinolinyl, dihydroisoquinolinyl, or indolyl, each of which is optionally substituted with 1, 2, 3, or 4 groups that are independently —C(O)NR 6 R 7 , —(C 1 -C 4 alkyl)-C(O)NR 6 R 7 , —NR 6 R 7 , hydroxy(C 1 -C 4 )alkyl, C 1 -C 4 dihydroxyalkyl, hydrogen, hydroxy, halogen, haloalkyl, alkyl, haloalkoxy, R 6 R 7 N—(C 1 -C 6 alkyl)-, —CO 2 —(C 1 -C 6 )alkyl, —N(R)C(O)NR 6 R 7 , or —N(R)C(O)—(C 1 -C 6 )alkoxy; wherein

R 6 and R 7 are independently at each occurrence H, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 alkoxy C 1 -C 6 alkyl, C 1 -C 6 alkoxycarbonyl, OH, C 1 -C 6 hydroxyalkyl, C 1 -C 6 dihydroxyalkyl, C 1 -C 6 thiohydroxyalkyl, —(C 1 -C 4 )alkyl-CO 2 -alkyl, pyridyl C 1 -C 6 alkyl, C 1 -C 6 alkanoyl, benzyl, phenyl C 1 -C 6 alkoxy, or phenyl C 1 -C 6 alkanoyl, wherein each of the above is unsubstituted or substituted with 1, 2, or 3 groups that are independently, halogen, C 3 -C 6 cycloalkyl, C 1 -C 6 alkoxy, piperidinyl C 1 -C 6 alkyl, morpholinyl C 1 -C 6 alkyl, piperazinyl C 1 -C 6 alkyl, OH, SH, NH 2 , NH(alkyl), N(alkyl)(alkyl), —O—-C 1 -C 4 alkanoyl, C 1 -C 4 alkyl, CF 3 , or OCF 3 .

8. The method according to claim 7 , wherein

Y 2 , Y 4 , and Y are independently halogen; and

Y 1 and Y 3 are both hydrogen.

9. The method according to claim 8 , wherein

X 1 and X 2 are independently H, methyl, —NR 6 R 7 , R 6 R 7 N—(C 1 -C 6 alkyl)-, —C(O)NR 6 R 7 , —(C 1 -C 4 alkyl)-C(O)NR 6 R 7 , hydroxy(C 1 -C 4 )alkyl, C 1 -C 4 dihydroxyalkyl, or —(C 1 -C 4 alkyl)-morpholinyl.

10. The method according to claim 9 , wherein

R 5 is pyridyl C 1 -C 6 alkyl, pyrimidinyl C 1 -C 6 alkyl, or pyrazinyl C 1 -C 6 alkyl, each of which is optionally substituted with 1, 2, or 3 groups that are independently hydroxy(C 1 -C 4 )alkyl, C 1 -C 4 dihydroxyalkyl, OH, halogen, CF 3 , (C 1 -C 4 )alkyl, OCF 3 , —NR 6 R 7 , —(C 1 -C 4 alkyl)-C(O)NR 6 R 7 , R 6 R 7 N—(C 1 -C 6 alkyl)-, or —C(O)NR 6 R 7 .

11. The method according to claim 3 wherein the compound is selected from the group consisting of:

3-[5-Bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N,4-dimethylbenzamide; Methyl 3-[4-[(2,4-difluorobenzy)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoate ; Methyl 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl ]-4-methylbenzoate; 3-[5-Bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide; 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-(methylthio)-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

(±) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methyl-N -{1-[(methylamino)carbonyl]methyl}benzamide;

(−) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methyl-N-{1-[(methylamino)carbonyl]methyl}benzamide;

(+) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methyl-N -{1-[(methylamino)carbonyl]methyl}benzamide;

(+)3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

(+) 3-[5-Bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N,4-dimethylbenzamide;

(+) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methyl-N -{1-[aminocarbonyl]methyl}benzamide;

(−) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2,3-dihydroxpropyl ]-4-methylbenzamide;

(±) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2R)-2,3-dihydroxypropyl]-4-methylbenzamide;

(+) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2R)-2,3-dihydroxypropyl]-4-methylbenzamide;

(+) N-[(1S)-1-(aminocarbony)ethyl]-3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin -1(6H)-yl]-4-methylbenzamide;

(±) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(1R)-2-hydroxy -1-methylethyl]-4-methylbenzamide;

(±) 3[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(1S)-2-hydroxy -1-methylethyl]-4-methylbenzamide;

(±)3[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2-hydroxypropyl ]-4-methylbenzamide;

(−)3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2-hydroxypropyl ]-4-methylbenzamide;

(+)3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2-hydroxypropyl ]-4-methylbenzamide;

(±)3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2R)-2-hydroxypropyl ]-4-methylbenzamide;

(+)3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2R)-2-hydroxypropyl ]-4-methylbenzamide;

(±) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl )-4-methylbenzamide;

(−) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl )-4-methylbenzamide;

(+) 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl) -4-methylbenzamide;

(±) N-[(1S)-1-(aminocarbonyl)propyl]-3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[1-(aminocarbonyl)methyl]-4-methylbenzamide;

3-[4[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoate;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methyl-N-{1-[(methylamino)carbonyl]methyl}benzamide;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2,3-dihydroxpropyl]-4-methylbenzamide;

N-[(1S)-1-(aminocarbonyl)ethyl]-3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(1S)-2-hydroxy-1-methylethyl ]-4-methylbenzamide;

3-[5-choro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(1R)-2-hydroxy-1-methylethyl ]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[1-(aminocarbonyl )methyl]-N,4-dimethylbenzamide;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(2R)-2,3-dihydroxypropyl]-4-methylbenzamide;

N-[(1R)-1-(aminocarbonyl)-2-hydroxyethyl]-3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin -1(6H)-yl]-4-methylbenzamide;

N-[(1R)-1-(aminocarbonyl)ethyl]-3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(1S)-2-hydroxy-1-methylethyl ]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(1R)-2-hydroxy-1-methylethyl ]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N,4-dimethylbenzamide;

N-[1-(aminocarbonyl)methyl]-3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

N-[(1R)-1-(aminocarbonyl)ethyl]-3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

N-[(1S)-1-(aminocarbonyl)propyl]-3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2-hydroxypropyl ]-4-methylbenzamide;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(2R)-2-hydroxypropyl ]-4-methylbenzamide;

5-chloro-6-[(2,4-difluorobenzyl)oxy]-3-(5-{[(3S)-3-hydroxypyrrolidin-1-yl]carbonyl}-2-methylphenyl)pyrimidin-4(3H)-one;

3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-methoxyethyl)-4-methylbenzamide;

5-chloro-6-[(2,4-difluorobenzyl)oxy]-3-(5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}-2-methylphenyl)pyrimidin-4(3H)-one;

3-[4-[(2,4-difluorobenzyl)oxy]-5-ethyl-6-oxopyrimidin-1(6H)-yl]-N-[(1R)-2-hydroxy-1-methylethyl]-4-methylbenzamide;

methyl 3[4-[(2,4-difluorobenzyl)oxy]-5-iodo-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoate;

methyl 3-[4-[(2,4-difluorobenzyl)oxy]-5-ethyl-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoate;

3-[4-[(2,4-difluorobenzyl)oxy]-5-ethyl-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-(methylamino)-6-oxopyrimidin-1(6H)-yl]-N,4dimethylbenzamide;

methyl 3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-(methylamino)-6-oxopyrimidin-1(6H)-yl]-4-methylbenzoate;

N-[1-(aminocarbonyl)methyl]-3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-(methylamino)-6-oxopyrimidin -1(6H)-yl]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-(methylamino)-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2,3-dihydroxypropyl]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methyl-N-{1-[(methylamino)carbonyl]methyl}benzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2,3-dihydroxypropyl ]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(2R)-2,3-dihydroxypropyl]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide;

N-[(1S)-1-(aminocarbonyl)ethyl]-3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2-hydroxypropyl ]-4-methylbenzamide;

3-[5-bromo-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin1 (6H)-yl]-N-[(2R)-2-hydroxypropyl]-4-methylbenzamide;

(±) 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide;

(−) 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide;

(+) 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide;

(±) 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methyl-N-{1-[aminocarbonyl]methyl}benzamide;

(−)3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methyl-N-{1-[aminocarbonyl]methyl}benzamide;

(±) 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methyl-N-{1-[(methylamino)carbonyl]methyl}benzamide;

(±) 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-4-methyl-N-{1-[(methylamino)carbonyl]methyl}benzamide;

±3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2S)-2-hydroxypropyl]-4-methylbenzamide;

±3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]-N-[(2R)-2-hydroxypropyl]-4-methylbenzamide;

3-benzyl-6-(benzyloxy)-5-bromopyrimidin-4(3H)-one;

3-benzyl-6-(benzyloxy)-pyrimidin-4(3H)-one; 4-{[5-bromo-4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]methyl}-N-methylbenzamide; and methyl 4-{[4-[(2,4-difluorobenzyl)oxy]-2-methyl-6-oxopyrimidin-1(6H)-yl]methyl}benzoate;

or a pharmaceutically acceptable salt thereof.

12. A method according to claim 11 wherein the compound is 3-[5-chloro-4-[(2,4-difluorobenzyl)oxy]-6-oxopyrimidin-1(6H)-yl]-N-(2-hydroxyethyl)-4-methylbenzamide or a pharmaceutically acceptable salt thereof.