Intravenous formulation with water-soluble cocrystals of acetylsalicylic acid and theanine

1. A method of making a parenteral fluid, comprising the steps of:

providing a quantity of acetylsalicylic acid;

adding a quantity of L-theanine to said quantity of acetylsalicylic acid to form a mixture comprising said quantity of acetylsalicylic acid and said quantity of L-theanine;

dissolving said mixture in a quantity of a first solvent to form a solution;

drying said solution for a length of time sufficient to produce a dried crystalline mass of an acetylsalicylic acid-theanine cocrystal composition;

dissolving said dried crystalline mass in a second solvent to form an acetylsalicylic acid -theanine cocrystal solution; and

adding said acetylsalicylic acid-theanine cocrystal solution to an infusion fluid.

2. The method of claim 1 , wherein the infusion fluid is selected from the group consisting of D5W, D10W, D50, D5 0.3% NS, D5 0.45% NS, 0.45% NS, D5 0.9% NS, 0.9% NS, 3% NaCl, D5RL, LR, and NaHCO 3 .

3. The method of claim 1 , wherein said dried crystalline mass has an aqueous solubility of at least about 9.4 mg/mL.

4. The method of claim 1 , further comprising adding a sugar alcohol to said solution.

5. The method of claim 4 , wherein said sugar alcohol has an L-configuration.

6. The method of claim 1 , wherein said first solvent is water.

7. The method of claim 1 , wherein said second solvent is water.

8. The method of claim 1 , wherein the pH of said acetylsalicylic acid-theanine cocrystal solution is physiologic.