Disclosed is a vaccine for edwardsiellosis and streptococcosis in a fish. Specifically, disclosed is a vaccine for edwardsiellosis in a fish, which comprises inactivated cells of (A) an Edwardsiella tarda strain derived from the target fish, and inactivated cells of (B) an Edwardsiella tarda strain derived from a fish other than the target fish, wherein, when the strain (A) is a typical Edwardsiella tarda strain, the strain (B) is an atypical Edwardsiella tarda strain, whereas when the strain (A) is an atypical Edwardsiella tarda strain, the strain (B) is a typical Edwardsiella tarda strain. Also specifically disclosed is a vaccine for edwardsiellosis and/or streptococcosis in a fish, which comprises the components mentioned above and inactivated cells of (C) Streptococcus iniae and/or Streptococcus parauberis.
1. A vaccine for edwardsiellosis in a target fish that is a bastard halibut or a red sea bream, comprising inactivated cells of (A) an Edwardsiella tarda strain obtained from the target fish, and inactivated cells of (B) an Edwardsiella tarda strain obtained from a fish other than the target fish, wherein, when the strain (A) is a typical Edwardsiella tarda strain, the strain (B) is an atypical Edwardsiella tarda strain, whereas when the strain (A) is an atypical Edwardsiella tarda strain, the strain (B) is a typical Edwardsiella tarda strain
wherein when the target fish is a bastard halibut, the fish other than the target fish is a red sea bream and when the target fish is a red seam bream, the fish other than the target fish is a bastard halibut.
2. The vaccine according to claim 1 , wherein the number of inactivated cells of the strain (A) to that of strain (B) is 1:(0.1 to 1).
3. The vaccine according to claim 1 , which is in the form of injection or oral administration.
4. The vaccine according to claim 2 , which is in the form of injection or oral administration.