HCV NS3 protease inhibitors
View Patent ↗The present invention relates to macrocyclic compounds of formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease, their synthesis, and their use treating or preventing HCV infections.
1. A compound of formula (I):
and/or a pharmaceutically acceptable salt or hydrate thereof, wherein:
p and q are independently 1 or 2;
R 1 and R 2 , together with the cyclopropyl ring to which they are attached, form the following bicyclic ring system:
wherein
is a single or double bond;
R 3 is C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 )alkyl, aryl(C 1 -C 8 )alkyl, or Het, wherein aryl is phenyl or naphthyl and said alkyl, cycloalkyl, or aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
Het is a 5- to 6-membered saturated cyclic ring having 1 or 2 heteroatoms selected from N, O and S, wherein said ring is optionally substituted with 1 to 3 substituents selected from halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
R 4 is H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 )alkyl, or aryl(C 1 -C 8 )alkyl; wherein aryl is phenyl or naphthyl and said alkyl, cycloalkyl, or aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
R 5 is H, halo, —OR 10 , C 1 -C 6 alkyl, —CN, —CF 3 , —SR 10 , —SO 2 (C 1 -C 6 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkoxy, C 1 -C 6 haloalkyl, —N(R 7 ) 2 , aryl, heteroaryl or heterocyclyl; wherein aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and heterocyclyl is a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein said aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkoxy, alkyl or alkoxy is optionally substituted with 1 to 4 substituents selected from the group consisting of halo, OR 10 , SR 10 , N(R 7 ) 2 , N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkoxy, NO 2 , CN, CF 3 , SO 2 (C 1 -C 6 alkyl), NR 10 SO 2 R 6 , SO 2 N(R 6 ) 2 , S(O)(C 1 -C 6 alkyl), NHCOOR 6 , NHCOR 6 , NHCONHR 6 , CO 2 R 10 , C(O)R 10 , and CON(R 10 ) 2 ; wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
R 6 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl(C 1 -C 5 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, or heterocyclyl(C 1 -C 8 alkyl), wherein said alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 2 W substituents or aryl is substituted by P(O)R 11 R 12 ; and wherein each aryl is independently phenyl or naphthyl, each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
Y is —C(═O)—, —SO 2 —, or —C(═N—CN)—;
Z is —C(R 10 ) 2 —, —O—, or —N(R 4 )—;
M is C 1 -C 12 alkylene or C 2 -C 12 alkenylene, wherein said alkylene or alkenylene is optionally substituted with 1 or 2 substituents selected from the group consisting of C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 alkyl), and aryl(C 1 -C 8 alkyl); and the 2 adjacent substituents of M are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
each R 7 is independently H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl(C 1 -C 5 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, or heterocyclyl(C 1 -C 8 alkyl), wherein said alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 2 W substituents; and wherein each aryl is independently phenyl or naphthyl, each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
each W is independently halo, —OR 10 , C 1 -C 6 alkyl, —CN, —CF 3 , —NO 2 , —SR 10 , —CO 2 R 10 , —CON(R 10 ) 2 , —C(O)R 10 , —N(R 10 )C(O)R 10 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkoxy, C 1 -C 6 haloalkyl, —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), halo(C 1 -C 6 alkoxy), —NR 10 SO 2 R 10 , —SO 2 N(R 10 ) 2 , —NHCOOR 10 , —NHCONHR 10 , aryl, heteroaryl or heterocyclyl; wherein aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and heterocyclyl is a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
each R 10 is independently H or C 1 -C 6 alkyl;
each R 11 is independently C 1 -C 6 alkyl, C 1 -C 4 alkenyl, —OR 13 , —N(R 10 )—V—CO 2 R 10 , —O—V—CO 2 R 10 , —S—V—CO 2 R 10 , —N(R 10 )(R 13 ), R 14 , or —N(R 10 )SO 2 R 6 ;
each R 12 is independently —OR 13 , —N(R 10 )—V—CO 2 R 10 , —O—V—CO 2 R 10 , —S—V—CO 2 R 10 , or —N(R 10 )(R 13 );
or R 11 and R 12 are optionally taken together, with the phosphorus atom to which they are attached, to form a 5- to 7-membered monocyclic ring;
each V is independently —CH(R 15 ) or C 1 -C 4 alkylene-CH(R 15 );
each R 13 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein said alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 2 substituents selected from the group consisting of aryl, aryl(C 1 -C 4 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl(C 1 -C 4 alkyl), heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, heterocyclyl(C 1 -C 4 alkyl), C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R10) 2 ; wherein each aryl is independently phenyl or naphthyl; each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
R 14 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl or heteroaryl, wherein aryl is phenyl or naphthyl, and heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and wherein said aryl or heteroaryl is optionally substituted with 1 to 2 substituents selected from the group consisting of C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R 10 ) 2 ; and
each R 15 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein said alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 2 substituents selected from the group consisting of C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R 10 ) 2 ; wherein each aryl is independently phenyl or naphthyl; each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S.
2. A compound of claim 1 , wherein p and q are 1.
3. A compound of claim 1 , wherein R 11 is Independently C 1 -C 6 alkyl, C 1 -C 4 alkenyl, or —OR 13 , and R 12 is independently —OR 13 .
4. A compound of claim 3 , wherein R 13 is H or C 1 -C 6 alkyl.
5. A compound of claim 3 , wherein R 11 is selected from the group consisting of —OCH 2 CH 3 , —CH 2 CH 3 , —CH 3 , —CH(CH 3 ) 2 , phenyl, —CH═CH 2 , —OH, —CH 2 CH 2 CH 3 , and —CH 2 CH 2 CH 2 CH 3 , and R 12 is —OH or —OCH 2 CH 3 .
6. A compound of claim 1 , wherein R 3 is C 1 -C 8 alkyl or C 3 -C 8 cycloalkyl.
7. A compound of claim 6 , wherein R 3 is —C(CH 3 ) 3 , cyclohexyl or cyclopentyl.
8. A compound of claim 1 , wherein R 5 is H.
9. A compound of claim 1 , wherein Z is —O—.
10. A compound of claim 1 , wherein Y is —C(═O)—.
11. A compound of claim 1 , wherein M is M is C 1 -C 12 alkylene or C 2 -C 12 alkenylene, wherein said alkylene or alkenylene is optionally substituted with 1 or 2 substituents selected from the group consisting of C 1 -C 8 alkyl.
12. A compound of claim 11 , wherein M is selected from the group consisting of —(CH 2 ) 4 C(CH 3 ) 2 (CH 2 )—, —(CH 2 ) 6 —, —(CH 2 ) 4 CH(CH 3 )CH 2 —, —CH═CH(CH 2 ) 2 C(CH 3 ) 2 CH 2 —, —CH═CH(CH 2 ) 2 CH(CH 3 )CH 2 —, —CH═CHCH 2 C(CH 3 ) 2 CH 2 —, —CH═CH(CH 2 ) 3 —, —CH═CH(CH 2 ) 4 —, —CH═CHCH 2 CH(CH 3 )CH 2 —, —(CH 2 ) 3 C(CH 3 ) 2 CH 2 —, —(CH 2 ) 5 —, and —(CH 2 ) 3 CH(CH 3 )CH 2 —.
13. A pharmaceutical composition comprising an effective amount of a compound of claim 1 , and a pharmaceutically acceptable carrier.
14. A pharmaceutical composition of claim 13 , further comprising a second therapeutic agent selected from the group consisting of a HCV antiviral agent, an immunomodulator, and an anti-infective agent.
15. A method of treating HCV infection comprising administering to a patient in need thereof a composition comprising a compound of formula (I):
and/or a pharmaceutically acceptable salt or hydrate thereof, wherein:
p and q are independently 1 or 2;
R 1 and R 2 , together with the cyclopropyl ring to which they are attached, form the following bicyclic ring system:
wherein
is a single or double bond;
R 3 is C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 )alkyl, aryl(C 1 -C 8 )alkyl, or Het, wherein aryl is phenyl or naphthyl and said alkyl, cycloalkyl, or aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
Het is a 5- to 6-membered saturated cyclic ring having 1 or 2 heteroatoms selected from N, O and S, wherein said ring is optionally substituted with 1 to 3 substituents selected from halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
R 4 is H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 )alkyl, or aryl(C 1 -C 8 )alkyl; wherein aryl is phenyl or naphthyl and said alkyl, cycloalkyl, or aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
R 5 is H, halo, —OR 10 , C 1 -C 6 alkyl, —CN, —CF 3 , —SR 10 , —SO 2 (C 1 -C 6 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkoxy, C 1 -C 6 haloalkyl, —N(R 7 ) 2 , aryl, heteroaryl or heterocyclyl; wherein aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and heterocyclyl is a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein said aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkoxy, alkyl or alkoxy is optionally substituted with 1 to 4 substituents selected from the group consisting of halo, OR 10 , SR 10 , N(R 7 ) 2 , N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkoxy, NO 2 CN, CF 3 , SO 2 (C 1 -C 6 alkyl), NR 10 SO 2 R 6 , SO 2 N(R 6 ) 2 , S(O)(C 1 -C 6 alkyl), NHCOOR 6 , NHCOR 6 , NHCONHR 6 , CO 2 R 10 , C(O)R 10 , and)CON(R 10 ) 2 ; wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
R 6 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl(C 1 -C 5 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, or heterocyclyl(C 1 -C 8 alkyl), wherein said alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 2 W substituents or aryl is substituted by P(O)R 11 R 12 ; and wherein each aryl is independently phenyl or naphthyl, each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
Y is —C(═O)—, —SO 2 —, or —C(═N—CN)—;
Z is —C(R 10 ) 2 —, —O—, or —N(R 4 )—;
M is C 1 -C 12 alkylene or C 2 -C 12 alkenylene, wherein said alkylene or alkenylene is optionally substituted with 1 or 2 substituents selected from the group consisting of C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 alkyl), and aryl(C 1 -C 8 alkyl); and the 2 adjacent substituents of M are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
each R 7 is independently H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl(C 1 -C 5 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, or heterocyclyl(C 1 -C 8 alkyl), wherein said alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 2 W substituents; and wherein each aryl is independently phenyl or naphthyl, each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
each W is independently halo, —OR 10 , C 1 -C 6 alkyl, —CN, —CF 3 , —NO 2 , —SR 10 , —CO 2 R 10 , —CON(R 10 ) 2 , —C(O)R 10 , —N(R 10 )C(O)R 10 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkoxy, C 1 -C 6 haloalkyl, —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), halo(C 1 -C 6 alkoxy), —NR 10 SO 2 R 10 , —SO 2 N(R 10 ) 2 , —NHCOOR 10 , —NHCONHR 10 , aryl, heteroaryl or heterocyclyl; wherein aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and heterocyclyl is a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
each R 10 is independently H or C 1 -C 6 alkyl;
each R 11 is independently C 1 -C 6 alkyl, C 1 -C 4 alkenyl, —OR 13 , —N(R 10 )—V—CO 2 R 10 , —O—V—CO 2 R 10 , —S—V—CO 2 R 10 , —N(R 10 )(R 13 ), R 14 , or —N(R 10 )SO 2 R 6 ;
each R 12 is independently —OR 13 , —N(R 10 )—V—CO 2 R 10 , —O—V—CO 2 R 10 , —S—V—CO 2 R 10 , or —N(R 10 )(R 13 );
or R 11 and R 12 are optionally taken together, with the phosphorus atom to which they are attached, to form a 5- to 7-membered monocyclic ring;
each V is independently —CH(R 15 ) or C 1 -C 4 alkylene-CH(R 15 );
each R 13 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein said alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 2 substituents selected from the group consisting of aryl, aryl(C 1 -C 4 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl(C 1 -C 4 alkyl), heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, heterocyclyl(C 1 -C 4 alkyl), C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R10) 2 ; wherein each aryl is independently phenyl or naphthyl; each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
R 14 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl or heteroaryl, wherein aryl is phenyl or naphthyl, and heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and wherein said aryl or heteroaryl is optionally substituted with 1 to 2 substituents selected from the group consisting of C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R 10 ) 2 ; and
each R 15 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein said alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 2 substituents selected from the group consisting of C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R 10 ) 2 ; wherein each aryl is independently phenyl or naphthyl; each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S.
16. A method of inhibiting HCV NS3 protease in a subject in need thereof, said method comprising administering to the subject an effective amount of a compound of formula (I):
and/or a pharmaceutically acceptable salt or hydrate thereof, wherein:
p and q are independently 1 or 2;
R 1 and R 2 , together with the cyclopropyl ring to which they are attached, form the following bicyclic ring system:
wherein
is a single or double bond;
R 3 is C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 )alkyl, aryl(C 1 -C 8 )alkyl, or Het, wherein aryl is phenyl or naphthyl and said alkyl, cycloalkyl, or aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
Het is a 5- to 6-membered saturated cyclic ring having 1 or 2 heteroatoms selected from N, O and S, wherein said ring is optionally substituted with 1 to 3 substituents selected from halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
R 4 is H, C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 )alkyl, or aryl(C 1 -C 8 )alkyl; wherein aryl is phenyl or naphthyl and said alkyl, cycloalkyl, or aryl is optionally substituted with 1 to 3 substituents selected from the group consisting of halo, —OR 10 , —SR 10 , —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , —C(O)R 10 , and —CON(R 10 ) 2 ;
R 5 is H, halo, —OR 10 , C 1 -C 6 alkyl, —CN, —CF 3 , —SR 10 , —SO 2 (C 1 -C 6 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkoxy, C 1 -C 6 haloalkyl, —N(R 7 ) 2 , aryl, heteroaryl or heterocyclyl; wherein aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and heterocyclyl is a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein said aryl, heteroaryl, heterocyclyl, cycloalkyl, cycloalkoxy, alkyl or alkoxy is optionally substituted with 1 to 4 substituents selected from the group consisting of halo, OR 10 , SR 10 , N(R 7 ) 2 , N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, halo(C 1 -C 6 alkoxy), C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkoxy, NO 2 , CN, CF 3 , SO 2 (C 1 -C 6 alkyl), NR 10 SO 2 R 6 , SO 2 N(R 6 ) 2 , S(O)(C 1 -C 6 alkyl), NHCOOR 6 , NHCOR 6 , NHCONHR 6 , CO 2 R 10 , C(O)R 10 , and CON(R 10 ) 2 ; wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
R 6 is C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl(C 1 -C 5 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, or heterocyclyl(C 1 -C 8 alkyl), wherein said alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 2 W substituents or aryl is substituted by P(O)R 11 R 12 ; and wherein each aryl is independently phenyl or naphthyl, each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
Y is —C(═O)—, —SO 2 —, or —C(═N—CN)—;
Z is —C(R 10 ) 2 —, —O—, or —N(R 4 )—;
M is C 1 -C 12 alkylene or C 2 -C 12 alkenylene, wherein said alkylene or alkenylene is optionally substituted with 1 or 2 substituents selected from the group consisting of C 1 -C 8 alkyl, C 3 -C 8 cycloalkyl(C 1 -C 8 alkyl), and aryl(C 1 -C 8 alkyl); and the 2 adjacent substituents of M are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
each R 7 is independently H, C 1 -C 6 alkyl, C 3 -C 6 cycloalkyl, C 3 -C 6 cycloalkyl(C 1 -C 5 )alkyl, aryl, aryl(C 1 -C 4 )alkyl, heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, or heterocyclyl(C 1 -C 8 alkyl), wherein said alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with 1 to 2 W substituents; and wherein each aryl is independently phenyl or naphthyl, each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
each W is independently halo, —OR 10 , C 1 -C 6 alkyl, —CN, —CF 3 , —NO 2 , —SR 10 , —CO 2 R 10 , —CON(R 10 ) 2 , —C(O)R 10 , —N(R 10 )C(O)R 10 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkoxy, C 1 -C 6 haloalkyl, —N(R 10 ) 2 , —N(C 1 -C 6 alkyl)O(C 1 -C 6 alkyl), halo(C 1 -C 6 alkoxy), —NR 10 SO 2 R 10 , —SO 2 N(R 10 ) 2 , —NHCOOR 10 , —NHCONHR 10 , aryl, heteroaryl or heterocyclyl; wherein aryl is phenyl or naphthyl, heteroaryl is a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and heterocyclyl is a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen;
each R 10 is independently H or C 1 -C 6 alkyl;
each R 11 is independently C 1 -C 6 alkyl, C 1 -C 4 alkenyl, —OR 13 ,) —N(R 10 )—V—CO 2 R 10 , —O—V—CO 2 R 10 , —S—V—CO 2 R 10 , —N(R 10 )(R 13 ), R 14 , or —N(R 10 )SO 2 R 6 ;
each R 12 is independently —OR 13 , —NR 10 —V—CO 2 R 10 , —O—V—CO 2 R 10 , —S—V—CO 2 R 10 , or —N(R 10 )(R 13 );
or R 11 and R 12 are optionally taken together, with the phosphorus atom to which they are attached, to form a 5- to 7-membered monocyclic ring;
each V is independently —CH(R 15 ) or C 1 -C 4 alkylene-CH(R 15 );
each R 13 is independently H, C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein said alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 2 substituents selected from the group consisting of aryl, aryl(C 1 -C 4 alkyl), C 3 -C 8 cycloalkyl, C 3 -C 8 cycloalkyl(C 1 -C 4 alkyl), heteroaryl, heteroaryl(C 1 -C 4 alkyl), heterocyclyl, heterocyclyl(C 1 -C 4 alkyl), C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R10) 2 ; wherein each aryl is independently phenyl or naphthyl; each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S;
R 14 is C 1 -C 6 alkyl, C 2 -C 6 alkenyl, aryl or heteroaryl, wherein aryl is phenyl or naphthyl, and heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen, and wherein said aryl or heteroaryl is optionally substituted with 1 to 2 substituents selected from the group consisting of C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R 10 ) 2 ; and
each R 15 is independently C 1 -C 6 alkyl, C 2 -C 6 alkenyl, C 3 -C 8 cycloalkyl, aryl, heteroaryl, or heterocyclyl, wherein said alkyl, alkenyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with 1 to 2 substituents selected from the group consisting of C 1 -C 6 alkyl, halo, —OC(O)OR 6 , —OC(O)R 6 , —OR 10 , —SR 10 , —N(R 10 ) 2 , —C(O)R 10 , —NO 2 , —CN, —CF 3 , —SO 2 (C 1 -C 6 alkyl), —S(O)(C 1 -C 6 alkyl), —NR 10 SO 2 R 6 , —SO 2 N(R 6 ) 2 , —NHCOOR 6 , —NHCOR 6 , —NHCONHR 6 , —CO 2 R 10 , and —C(O)N(R 10 ) 2 ; wherein each aryl is independently phenyl or naphthyl; each heteroaryl is independently a 5- or 6-membered aromatic ring having 1, 2 or 3 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and each heterocyclyl is independently a 5- to 7-membered saturated or unsaturated non-aromatic ring having 1, 2, 3 or 4 heteroatoms selected from N, O and S, attached through a ring carbon or nitrogen; and wherein the 2 adjacent substituents of said cycloalkyl, cycloalkoxy, aryl, heteroaryl or heterocyclyl are optionally taken together to form a 3- to 6-membered cyclic ring containing 0 to 3 heteroatoms selected from N, O and S.