METHODS FOR REDUCING PHOSPHATE ABSORPTION
It is disclosed here a method for reducing phosphate absorption in a human or non-human animal subject wherein the subject consumes a diet containing phytic acid or phytate and either has or is at risk of developing hyperphosphatemia. The method includes the step of administering orally to the subject an anti-phytic acid (C 6 H 6 [OPO(OH) 2 ] o ) antibody or an anti-phytate antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.
1 . A method of reducing phosphate absorption in a human or non-human animal subject wherein the subject consumes a diet containing phytic acid or phytate and either has or is at risk of developing hyperphosphatemia, the method comprising the step of:
administering orally to the subject an anti-phytic acid antibody or an anti-phytate antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.
2 . The method of claim 1 , wherein the subject has a kidney disease.
3 . The method of claim 2 , wherein the kidney disease is selected from end stage renal disease, acute renal failure, chronic renal failure, polycystic kidney disease, chronic kidney disease, acute tubular necrosis, an infection that reduces kidney function, and a urinary tract obstruction.
4 . The method of claim 1 , wherein the subject is receiving a vitamin D compound.
5 . The method of claim 1 , wherein the antibody is an IgY antibody.
6 . The method of claim 1 , wherein the antibody is obtained from an avian egg.
7 . The method of claim 1 , wherein the antibody is administered with a phosphate binder.
8 . The method of claim 1 , wherein the subject is a human subject.
9 . The method of claim 1 , further comprising the steps of measuring the serum phosphate concentration after the antibody is administered and comparing the concentration to that before the antibody is administered.
10 . A method of reducing phosphate absorption in a human subject who has a kidney disease, receives a vitamin D compound, and consumes a diet containing phytic acid or phytate wherein the vitamin D compound renders the phytic phosphate in the diet available for absorption, the method comprising the step of:
administering orally to the human subject an anti-phytic acid antibody or an anti-phytate antibody in an amount effective to reduce or maintain the serum phosphate concentration in the subject.
11 . The method of claim 10 , wherein the kidney disease is selected from end stage renal disease, acute renal failure, chronic renal failure, polycystic kidney disease, chronic kidney disease, acute tubular necrosis, an infection that reduces kidney function, and a urinary tract obstruction.
12 . The method of claim 10 , wherein the antibody is an IgY antibody.
13 . The method of claim 10 , wherein the antibody is obtained from an avian egg.
14 . The method of claim 10 , wherein the antibody is administered with a phosphate binder.
15 . The method of claim 10 , further comprising the steps of measuring the serum phosphate concentration after the antibody is administered and comparing the concentration to that before the antibody is administered.