Nuclear translocation peptide
The present invention provides a peptide comprising amino acid sequences R I, F I and R I G C and containing 25 or fewer amino acid residues, and capable of transporting a functional molecule into a cell, and also into a nucleus, more efficiently than a previous PTD.
1. A peptide, consisting of SEQ ID NO: 1 or SEQ ID NO: 3.
2. The peptide according to claim 1 , used as a vector for transport of a biologically active substance into a cell or a nucleus.
3. A conjugate, wherein the peptide according to claim 1 is joined directly, or indirectly to a functional molecule via a linker molecule.
4. The conjugate according to claim 3 , wherein the functional molecule is a biologically active substance selected from a group consisting of nucleic acids, amino acids, lipids, sugars, and other polymer compounds.
5. The conjugate according to claim 3 , wherein the functional molecule is a magnetic nanoparticle or a liposome.
6. The peptide of claim 1 , consisting of the amino acid sequence of SEQ ID NO:1.
7. The peptide of claim 1 , consisting of the amino acid sequence of SEQ ID NO:3.