Synthesis of thiohydantoins
A novel synthesis of the anti-androgen, A52, which has been found to be useful in the treatment of prostate cancer, is provided. A52 as well as structurally related analogs may be prepared via the inventive route. This new synthetic scheme may be used to prepare kilogram scale quantities of pure A52.
1. A method of synthesizing a compound of formula:
the method comprising:
deprotecting the protected amine of a compound of formula:
under acidic conditions to provide a compound of formula:
2. The method of claim 1 , wherein the step of deprotecting is performed using trifluoro acetic acid (TFA).
3. The method of claim 1 , wherein the protected amine of a compound of formula:
is synthesized in a method comprising:
cyanating a compound of formula:
using a transition metal catalyst and a source of cyanide to provide a compound of formula:
4. The method of claim 3 , wherein the step of cyanating is performed using a palladium-catalyzed cyanation reaction.
5. The method of claim 3 , wherein the step of cyanating is performed using a palladium catalyst with a phosphorus containing ligand, and a source of cyanide.
6. The method of claim 3 , wherein the step of cyanating is performed using tris(dibenzylideneacetone)dipalladium (Pd 2 (dba) 3 ) with a phosphorus containing ligand, and Zn(CN) 2 .
7. The method of claim 3 , wherein the compound of formula:
is synthesized in a method comprising:
aminating a compound of formula:
wherein X is bromine or iodine, using p-methoxybenzylamine to provide a compound of formula:
8. The method of claim 7 , wherein X is I.
9. The method of claim 7 , wherein the step of aminating is performed in the presence of a transition metal catalyst.
10. The method of claim 7 , wherein the step of aminating is performed in the presence of a palladium catalyst.
11. The method of claim 7 , wherein the step of aminating is performed in the presence of tris(dibenzylideneacetone)dipalladium (Pd 2 (dba) 3 ), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos), and sodium tert-butoxide.
12. The method of claim 7 , wherein the compound of formula:
is synthesized in a method comprising:
chlorinating a compound of formula:
wherein X is bromine or iodine, using POCl 3 or POCl 3 /PCl 5 to provide a compound of formula:
13. The method of claim 12 , wherein the step of chlorinating is performed using POCl 3 .
14. The method of claim 12 , wherein the compound of formula:
is synthesized in a method comprising:
halogenating a compound of formula:
using a brominating or iodinating reagent to provide a compound of formula:
wherein X is bromine or iodine.
15. The method of claim 14 , wherein X is iodine, and the step of halogenating is performed using N-iodosuccinimide (NIS).
16. The method of claim 14 , wherein X is bromine, and the step of halogenating is performed using N-bromosuccinimide (NBS).
17. The method of claim 12 , wherein the step of chlorinating is performed using POCl 3 /PCl 5 .