Locally active “soft” antiandrogens
The present invention relates to antiandrogenic compounds which may be administered for the treatment of androgen excess in the skin and by way of consequence, the treatment of acne, baldness or hirsuitism in subject or patient. These compounds have the general chemical structure (I, II, III or IV).
1. A compound according to the chemical structure:
wherein R b is an optionally substituted C 1 -C 6 alkyl group.
2. The compound according to claim 1 , wherein R b is an optionally substituted C 2 or C 3 alkyl group.
3. The compound according to claim 1 which is
wherein R b is an ethyl group.
4. A pharmaceutical composition comprising an effective amount of a compound according to claim 1 in combination with a pharmaceutically acceptable carrier, additive or excipient.
5. A pharmaceutical composition comprising an effective amount of a compound according to claim 2 in combination with a pharmaceutically acceptable carrier, additive or excipient.
6. A pharmaceutical composition comprising an effective amount of a compound according to claim 3 in combination with a pharmaceutically acceptable carrier, additive or excipient.
7. The composition according to claim 4 in topical dosage form.
8. The composition according to claim 5 in topical dosage form.
9. The composition according to claim 6 in topical dosage form.
10. A method of treating acne in a patient in need thereof comprising administering an effective amount of a composition according to claim 4 to said patient.
11. A method of treating acne in a patient in need thereof comprising administering an effective amount of a composition according to claim 7 to said patient.
12. A method of treating acne in a patient in need thereof comprising administering an effective amount of a composition according to claim 8 to said patient.
13. A method of treating acne in a patient in need thereof comprising administering an effective amount of a composition according to claim 9 to said patient.
14. A method of treating baldness in a patient in need thereof comprising administering an effective amount of a composition according to claim 4 to said patient.
15. A method of treating baldness in a patient in need thereof comprising administering an effective amount of a composition according to claim 7 to said patient.
16. A method of treating baldness in a patient in need thereof comprising administering an effective amount of a composition according to claim 8 to said patient.
17. A method of treating baldness in a patient in need thereof comprising administering an effective amount of a composition according to claim 9 to said patient.
18. The method according to claim 14 wherein said baldness is female pattern baldness.
19. The method according to claim 15 wherein said baldness is female pattern baldness.
20. The method according to claim 16 wherein said baldness is female pattern baldness.
21. The method according to claim 17 wherein said baldness is female pattern baldness.
22. The method according to claim 14 wherein said baldness is male pattern baldness.
23. The method according to claim 15 wherein said baldness is male pattern baldness.
24. The method according to claim 16 wherein said baldness is male pattern baldness.
25. The method according to claim 17 wherein said baldness is male pattern baldness.
26. A method of treating hirsutism in a patient in need thereof comprising administering an effective amount of a composition according to claim 4 to said patient.
27. A method of treating hirsutism in a patient in need thereof comprising administering an effective amount of a composition according to claim 7 to said patient.
28. A method of treating hirsutism in a patient in need thereof comprising administering an effective amount of a composition according to claim 8 to said patient.
29. A method of treating hirsutism in a patient in need thereof comprising administering an effective amount of a composition according to claim 9 to said patient.
30. The method according to claim 26 wherein said patient is a female.
31. The method according to claim 27 wherein said patient is a female.
32. The method according to claim 28 wherein said patient is a female.
33. The method according to claim 29 wherein said patient is a female.
34. A method of treating seborrhea in a patient in need thereof comprising administering an effective amount of a composition according to claim 4 to said patient.
35. A method of treating seborrhea in a patient in need thereof comprising administering an effective amount of a composition according to claim 7 to said patient.
36. A method of treating seborrhea in a patient in need thereof comprising administering an effective amount of a composition according to claim 8 to said patient.
37. A method of treating seborrhea in a patient in need thereof comprising administering an effective amount of a composition according to claim 9 to said patient.