Oxo-imidazolyl compounds
Compounds represented by Formula I and II, or pharmaceutically acceptable salts thereof: inhibit bacterial 2-epimerase and are useful anti-infective agents.
1. A compound represented by Formula I:
or a pharmaceutically acceptable salt thereof, wherein
X is O or S;
Y is S;
Z is O;
A is phenyl;
B is phenyl; or A is phenyl and B is CH 3 ; or A is bromo and B is phenyl;
(R 1 ) n is H;
R 2 in each instance independently is halo, methoxy, or OCF 3 ;
R 3 is H;
R 4 in each instance independently is C 0-4 alkyl, or a single-ringed aryl, hetaryl, or hetcyclyl; and
m is 1 or 2 and mm is 0.
2. The compound according to claim 1 , wherein X is S.
3. The compound according to claim 1 , wherein X is O.
4. The compound according to claim 1 , wherein X is O, A is phenyl, and B is phenyl.
5. The compound according to claim 1 selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
6. The compound according to claim 1 consisting of
or a pharmaceutically acceptable salt thereof.
7. A composition comprising a compound according to claim 1 and a pharmaceutically acceptable excipient.
8. A method for treating infections from Staphylococcus aureus, Staphylococcus aureus (MRSA), Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus pneumonia, Streptococcus agalactiae , Group C streptococcus , Group G streptococcus, Enterococcus jaecalis, Enterococcus jaecium, Bacillus anthracis, Bacillus cereus, Escherichia coli, Pseudomonas areuginosa, Neisseria meningitides , or Neisseria gonorrhoeae comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 1 .