Integrated locking device with active sealing

1. An endoscope biopsy cap, comprising:

an outer shell having an opening formed therein and a base, the outer shell including threads formed thereon;

a locking member coupled to the outer shell for securing the position of a medical device disposed in the opening;

an inner seal member disposed within the outer shell; and

an actuator coupled to the base for shifting the inner seal member between an unsealed configuration and a sealed configuration;

wherein the actuator includes a rotatable ring member, the rotatable ring member including threads formed thereon, the rotatable ring member being threadably coupled to the outer shell.

2. The cap of claim 1 , wherein the inner seal member includes a first seal region and a second seal region, wherein the first seal region is configured to seal against the port, and wherein the second seal region is configured to seal against a device extending through the inner seal member.

3. An endoscope assembly, comprising:

an endoscope having a channel formed therein and a port that provides access to the channel:

a cap coupled to the port, the cap including:

a base;

an outer shell including a chuck that is configured to shift between a first position and a second position;

a locking member coupled to the shell;

an inner seal member disposed within the outer shell;

one or more openings extending through the cap and into the channel; and

an actuator coupled to an outer surface of the outer shell for shifting the inner seal member between an unsealed configuration and a sealed configuration, the actuator configured to shift the chuck between the first position and the second position; and

wherein each of the chuck and the actuator include threads by which the chuck and the actuator are threadably coupled.