Salts of imidazole-5-carboxylic acid derivatives, a method for preparing same and pharmaceutical compositions comprising same
The present invention provides pharmaceutically acceptable salts of imidazole-5-carboxylic acid derivatives, methods for preparing same and pharmaceutical compositions comprising same. The salts obtained by the present invention can be easily dissolved in common solvents, such as water and methanol. The bioavailability thereof is good in animal body. Thereby it is applicable to be developed as a normal preparation for treating hypertension.
1. A pharmaceutically acceptable salt of formula (I)
wherein R is selected from the group consisting of hydrogen, straight or branched C 1 -C 4 alkyl, or C 3 -C 7 cycloalkyl, wherein said alkyl or cycloalkyl group is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, CI, Br, and OH;
M is metal ion or ammonium ion, where the metal ion is potassium, sodium, or calcium.
2. The salt according to claim 1 , wherein R is selected from the group consisting of straight or branched C 2 -C 4 alkyl.
3. The salt according to claim 1 , wherein R is selected from the group consisting of ethyl, isopropyl or tertiary butyl.
4. The salt according to claim 1 , wherein R is isopropyl.
5. The salt according to claim 1 , wherein the salt is a potassium salt, sodium salt or calcium salt.
6. A method for preparing a pharmaceutically acceptable salt of formula (I) as in claim 1 comprising the following steps:
(a) reacting, in an inert organic solvent, a compound of formula (II) with reagents which can provide a metal ion or ammonium ion to form a salt of formula (I),
wherein R is selected from the group consisting of hydrogen, straight or branched C 1 -C 4 alkyl, or C 3 -C 7 cycloalkyl, wherein alkyl or the cycloalkyl group is unsubstituted or substituted by 1-3 substituents selected from the group consisting of F, CI, Br, and OH,
M is a metal ion or ammonium ion, where the metal ion is potassium, sodium, or calcium; and (b) isolating the salt of formula (I) from a mixture of the reaction in (a).
7. A pharmaceutical composition comprising the pharmaceutically acceptable salt according to claim 1 and a pharmaceutically acceptable carrier.