Compositions for regulation of tumor necrosis factor-alpha
View Patent ↗The present invention relates to compositions and methods relating to an interleukin18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (TAIF) or interleukin-32 (IL-32). In particular, the present invention provides compositions and methods for treating autoimmune diseases and cancer, in part by regulation of tumor necrosis factor-alpha expression.
1. A purified human IL32 alpha protein consisting essentially of an amino acid sequence set forth in SEQ ID NO:7.
2. The protein of claim 1 , wherein said IL-32 alpha protein is a recombinant protein expressed in a cell selected from the group consisting of a bacterial cell, a yeast cell, an insect cell, and a mammalian cell.
3. The protein of claim 2 , wherein said recombinant protein is a fusion protein.
4. A composition for stimulating TNFα comprising the purified human IL32 alpha protein of claim 1 and at least one carrier.