IP Library › Granted Patent US 8,445,495
Granted Patent B2
US 8,445,495 · App. 12/483,093 · Granted May 21, 2013

Certain Chemical entities, compositions and methods

Inventors: Bradley P. Morgan (Moraga, CA); David J. Morgans, Jr. (Los Altos, CA); Alex Muci (San Francisco, CA); Pu-Ping Lu (Foster City, CA); Erica A. Kraynack (Belmont, CA); Todd Tochimoto (Foster City, CA)
Assignee: Cytokinetics, Inc.
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Quick Facts
Patent No.
US 8,445,495
App. No.
12/483,093
Granted
May 21, 2013
Kind
B2
Abstract

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.

Claims (4)

1. A method of increasing extent but not velocity of cardiac contraction comprising administering to a human a compound of formula

or a pharmaceutically acceptable salt thereof.

2. A method of increasing extent of contraction but not ±dP/dt comprising administering to a human a compound of formula

or a pharmaceutically acceptable salt thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 23, 2014
From: MORGAN, BRADLEY P.; MORGANS, DAVID J., JR.; MUCI, ALEX; LU, PU-PING; KRAYNACK, ERICA A.; TOCHIMOTO, TODD
To: CYTOKINETICS, INC.
Reel/Frame 034022/0178 →
Continuity (5)
Continuation 11640438 · Dec 14, 2006
Provisional Application 60751400 · Dec 15, 2005
Provisional Application 60756356 · Jan 4, 2006
Provisional Application 60817975 · Jun 29, 2006
Related Publication 20100029680A1 · Feb 4, 2010