Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage
The present invention provides compositions comprising mesenchymal stem cells (MSCs), and methods for their novel use in the repair of cardiac damage and treatment of inflammatory diseases. The invention also provides methods for using TSG-6 protein that is secreted by MSCs under certain conditions, for repair of cardiac damage and inflammatory disease. The compositions of the invention may be particularly useful in restoring cardiac function following cardiac damage, including, but not limited to, myocardial infarction, as well as in reducing symptoms of inflammatory disease.
1. A method of reducing the size of a myocardial infarction in a mammalian subject, comprising:
(a) administering to said mammalian subject, immediately after the occurrence of said myocardial infarction, tumor necrosis factor-alpha stimulating gene 6 (TSG-6) protein, wherein said TSG-6 protein is administered in an amount of about 100 μg; and
(b) administering to said mammalian subject, at 24 hours after the occurrence of said myocardial infarction, said TSG-6 protein in an amount of about 100 μg.
2. The method of claim 1 wherein said mammalian subject is a human.
3. The method of claim 1 wherein said TSG-6 protein is administered intravenously.