Combination of IAP inhibitors and FLT3 inhibitors
The present invention relates to methods of treating hematological malignancies, including acute myeloid leukemia (AML), comprising the combination of a compound that inhibits the binding of the Smac protein to IAPs (“IAP inhibitor”) and one or more pharmaceutically active agents; pharmaceutical compositions comprising said combination; and a commercial package comprising said combination. The present invention also relates to the use of IAP inhibitors in combination with one or more pharmaceutically active agents for the preparation of a medicament to treat hematological malignancies, including AML.
1. A method of treating a warm-blooded animal having acute myeloid leukemia (AML), comprising administering to said animal a therapeutically effective amount of (a) (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl ]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, or a pharmaceutically salt thereof, in combination with (b) midostaurin, or a pharmaceutically salt thereof.
2. A method according to claim 1 , wherein the AML is resistant to conventional chemotherapy.
3. A method according to claim 1 , wherein the warm-blooded animal is a human.
4. method according to claim 3 , wherein the human is a juvenile human.
5. A combination which comprises (a) (S)-N-((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, or a pharmaceutically salt thereof, and midostaurin, or a pharmaceutically salt thereof.
6. A pharmaceutical composition which comprises a combination as defined in claim 5 .