IP Library Granted Patent US 8,299,277
Granted Patent B2
US 8,299,277 · App. 12/516,722 · Granted Oct 30, 2012

Radiation protection drug containing tocopherol or tocotrienol compound ester derivative as active ingredient

Assignees: National Institute of Radiological Sciences; Fukuoka University
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Quick Facts
Patent No.
US 8,299,277
App. No.
12/516,722
Granted
Oct 30, 2012
Kind
B2
Abstract

Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.

Claims (14)

1. A method for treating or reducing side effects caused by exposure to radiotherapy or radiodiagnosis, which comprises administering to a patient in need thereof, a therapeutically effective amount of a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof:

wherein Q is a group represented by formula

R 1 is a methyl group;

R 2 is a group (i) represented by general formula:

(R) 2 N(CH 2 ) 1 CO—

(wherein each of the two Rs, which may be the same or different, is a hydrogen atom or a C 1-4 alkyl group, and l is 1 to 4), or

(R 5 ) 2 N(CH 2 ) m CO—  (3)

(wherein each of the two R 5 s, which may be the same or different, is a hydrogen atom or a C 1-4 alkyl group, and m is 0 to 3);

a group (ii) represented by general formula:

(wherein n is 0 to 2, R is as defined above, and R′ is a side chain of an amino acid selected from the group consisting of alanine, arginine, valine, leucine, isoleucine, asparagine, aspartic acid, glutamine, glutamic acid, phenylalanine, methionine, cysteine, serine, threonine, tyrosine, proline, hydroxyproline, histidine and lysine); or

a group (iii) represented by general formula:

(wherein each of the two Ys, which may be the same or different, is —OH, —O − , or —OA wherein A is an alkali metal); and

each of R 3 and R 4 , which may be the same or different, is a hydrogen atom or a C 1-4 alkyl group.

2. The method as claimed in claim 1 , wherein said compound represented by the general formula (I) is d-α-tocopherol N,N-dimethylglycine ester, d-γ-tocotrienol N,N-dimethylglycine ester, d-α-tocotrienol N,N-dimethylglycine ester, d-γ-tocopherol phosphate disodium salt, dl-α-tocopherol phosphate disodium salt, or d-γ-tocopherol N-methyl-L-proline ester.

Assignments (2)
CHANGE OF NAME Recorded Dec 12, 2018
From: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES
To: NATIONAL INSTITUTES FOR QUANTUM AND RADIOLOGICAL SCIENCE AND TECHNOLOGY
Reel/Frame 048999/0314 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2009
From: ANZAI, KAZUNORI; UENO, MEGUMI; YAKUMARU, HARUKO; UEDA, JUNICHI; AKASHI, MAKOTO; KOBAYASHI, SHIZUKO; TAKATA, JIRO; IKOTA, NOBUO
To: NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES; FUKUOKA UNIVERSITY
Reel/Frame 022882/0399 →
Priority Claims (1)
JP 2006-325408 · Dec 1, 2006 · national
Continuity (1)
Related Publication 20100048512A1 · Feb 25, 2010