NMDAR Biomarkers for Diagnosing and Treating Cerebral Ischemia
Provided are methods for detecting various subunits and isoforms of NMDA receptors to help diagnose and differentiate (1) the anatomical location of NMDA receptor over-expression, and (2) ischemic conditions in the central and peripheral nervous systems. Further provides are therapeutic strategies and interventions for the treatment and prevention of stroke, cardiovascular disease, and ischemic lesions in the brain and peripheral nervous system, and pulmonary disorders based on the results of such diagnoses.
1 - 15 . (canceled)
16 ) An isolated peptide comprising SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 OR SEQ ID NO:4, or an analog thereof.
17 ) The peptide of claim 16 linked to a diagnostic substrate or indicator reagent.
18 ) The isolated peptide of claim 16 comprising SEQ ID NO:1.
19 ) The isolated peptide of claim 16 comprising SEQ ID NO:2.
20 ) The isolated peptide of claim 16 comprising SEQ ID NO:3.
21 ) The isolated peptide of claim 16 comprising SEQ ID NO:4.
22 ) An isolated antibody that is specific for a peptide comprising SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 OR SEQ ID NO:4, or an analog thereof.
23 ) The isolated antibody of claim 22 linked to a diagnostic substrate or indicator reagent.
24 ) The isolated antibody of claim 22 wherein said peptide has SEQ ID NO:1.
25 ) The isolated antibody of claim 22 wherein said peptide has SEQ ID NO:2.
26 ) The isolated antibody of claim 22 wherein said peptide has SEQ ID NO:3.
27 ) The isolated antibody of claim 22 wherein said peptide has SEQ ID NO:4.
28 ) An isolated nucleic acid that encodes for a peptide comprising SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3 OR SEQ ID NO:4, or an analog thereof.
29 - 42 . (canceled)