Method of treating intrauterine inflammation
A method of treating intrauterine inflammation in a subject associated with intrauterine bacterial infection includes administering to the subject a therapeutically effective amount of a toll-like receptor 4 antagonist. The therapeutically effective amount administered to the subject is an amount effective in reducing intrauterine inflammation in the subject.
1. A method of inhibiting bacterial induced fetal death in a pregnant subject at risk of developing placental inflammation response associated with intrauterine bacterial infection, the method comprising:
administering to the pregnant subject with intrauterine bacterial infection a therapeutically effective amount of a toll-like receptor 4 antagonist, wherein the therapeutically effective amount is an amount effective to reduce intrauterine inflammation and inhibit bacterial induced fetal death in the pregnant subject.
2. The method of claim 1 , the toll-like receptor 4 antagonist comprising a monophosphoryl lipid A analog.
3. The method of claim 1 , the toll-like receptor 4 antagonist comprising an aminoalkyl-glucosaminide-phosphate (AGP).
4. The method of claim 3 , the AGP comprising the structure:
or a pharmaceutically acceptable salt or phosphate ester thereof.
5. The method of claim 1 wherein the toll-like receptor 4 antagonist is administered to the subject by intravenous infusion.
6. The method of claim 1 , wherein the toll-like receptor 4 antagonist is administered to the subject topically.
7. The method of claim 1 , wherein the bacterial induced fetal death comprising gram negative bacterial induced fetal death.
8. The method of claim 7 , wherein the gram negative bacteria is fusobacterium nucleatum.