Herbal composition and process for its preparation
A herbal composition comprising a therapeutically effective amount of the extract of Piper betle leaves as an active ingredient either alone, or with a pharmaceutically acceptable excipient. A process for the preparation of the herbal composition is provided. The herbal composition is adapted for the treatment of chronic myeloid leukemia (CML; chronic myelogenous leukemia) showing resistance to treatment with imatinib (Gleevec® or Glivec®).
1. A method for treating imatinib-resistant chronic myeloid leukemia in a patient comprising administering to the patient
a composition comprising a therapeutically effective amount of an extract of Piper betle leaves as an active ingredient either alone or with at least one pharmaceutically acceptable excipient, wherein, in the imatinib-resistant chronic myeloid leukemia, in the patient the resistance to imatinib is caused by Bcr-Abl mutation.
2. The method according to claim 1 , wherein said extract is administered orally, parenterally, subcutaneously, intravenously or intraarticularly.
3. The method according to claim 2 , wherein said extract is administered orally.
4. The method according to claim 3 , wherein said extract is formulated in the form of a tablet, capsule, granule, syrup or suspension.
5. The method according to claim 2 , wherein said extract is administered parenterally.
6. The method according to claim 1 , wherein the extract is administered in a dosage ranging from about 1 g to about 20 g per day.
7. The method according to claim 1 , wherein said composition comprises about 5% to about 50% (w/w) of the extract of Piper betle leaves.