Prophylactic and/or therapeutic agent for functional gastrointestinal disorders
The present inventors conducted dedicated studies, and as a result discovered that propionic acid bacteria fermentation products have a preventive/therapeutic effect on functional gastrointestinal disorders in in vitro tests and tests using patients with irritable bowel syndrome, and completed the present invention. Specifically, the present inventors discovered, in in vitro tests, that the products have an effect of increasing the intestinal contraction frequency without changing the intestinal contractile force in a distal colon-specific manner. Moreover, effects of improving the defecation condition, general abdominal condition, and health-related QOL in patients with irritable bowel syndrome were also found. Furthermore, propionic acid bacteria fermentation products can be taken in large amounts. Therefore, the propionic acid bacteria fermentation products can be expected to have an effect of preventing/treating functional gastrointestinal disorders safely.
1. A method for treating a human patient with constipation type-irritable bowel syndrome without organic gastrointestinal disease, wherein said method comprises:
determining whether the patient has an organic abnormality and a decrease in peristalsis in the whole colon with spastic constipation;
determining that the patient suffers from constipation type-irritable bowel syndrome without organic gastrointestinal disease if the patient has no organic abnormality, but has a decrease in peristalsis in the whole colon with spastic constipation; and
orally administering an effective amount of a whey fermentation product of Propionibacterium freudenreichii ET-3 (FERM BP-8115) to the patient for 15 to 28 days;
wherein the oral administration of the whey fermentation product of Propionibacterium freudenreichii ET-3 (FERM BP-8115) to the patient for 15 to 28 days increases the intestinal contraction frequency of the patient without changing the intestinal contractile force of the patient, thereby treating constipation type-irritable bowel syndrome in the patient.
2. The method of claim 1 , wherein the whey fermentation product is prepared from a culture medium containing a nutrient source selected from the group consisting of whey, a whey protein concentrate (WPC), a whey protein isolate (WPI), and an enzyme-treated product thereof.
3. The method of claim 2 , wherein the nutrient source is an enzyme-treated product of whey.
4. The method of claim 2 , wherein the whey fermentation product is heat-sterilized or dried when being prepared.