Methods and compositions related to inhibition of viral entry
Disclosed are compositions and methods for inhibiting viral entry.
1. An isolated composition comprising at least one peptide that interacts with the N-trimer pocket of a viral transmembrane protein wherein the at least one peptide comprises the amino acid sequence of SEQ ID NO: 36.
2. The composition of claim 1 , wherein the at least one peptide is linked to at least one other peptide.
3. The composition of claim 2 , wherein a crosslinker is used to multimerize the peptides.
4. The composition of claim 3 , wherein the crosslinker is PEG.
5. The composition of claim 2 , wherein the peptides are crosslinked into branched structures.
6. The composition of claim 2 , wherein the N-termini of the peptides are crosslinked.
7. The composition of claim 2 , wherein the C-termini of the peptides are crosslinked.
8. The composition of claim 2 , wherein the N-terminus of one peptide and the C-terminus of the other peptide are crosslinked.
9. The composition of claim 1 , wherein the viral transmembrane protein is HIV gp41.
10. The composition of claim 1 , wherein the at least one peptide is selected from any one of SEQ ID NOS: 3, 4, 5, 6, 7, 8, 9, 12, 13, 23, 24, 25, 26, 27, 28, 29, or a fragment thereof.
11. The composition of claim 1 , wherein the composition inhibits viral entry into a cell.
12. The composition of claim 1 , wherein at least one peptide is a D-peptide.
13. The composition of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.