G-substrate for the treatment and prevention of parkinson's disease
The invention features methods and compositions for the treatment and prevention of Parkinson's Disease.
1. A method for treating Parkinson's Disease in a patient, said method comprising increasing the level of G-substrate in the midbrain dopaminergic neurons of said patient, wherein said method comprises administering to said patient a viral vector comprising a polynucleotide encoding said G-substrate, operably linked to a promoter, wherein neurons in the patient take up the viral vector and express G-substrate.
2. The method of claim 1 , wherein said midbrain dopaminergic neurons are located in the substantia nigra A9 region.
3. The method of claim 1 , wherein said viral vector is selected from the group consisting of an adenovirus, adeno-associated virus, and retrovirus.
4. The method of claim 1 , wherein said viral vector is a lentiviral vector.
5. The method of claim 1 , wherein said viral vector is administered to the substantia nigra.
6. The method of claim 1 , wherein said viral vector encodes a biologically active fragment of G-substrate comprising the amino acid sequence of SEQ ID NO: 4.