Preparation and uses of polyarylates
View Patent ↗The present invention is directed to polyarylates comprising repeating units having the structure: as well as their preparation and use as cell growth substrates.
1. A tyrosine-derived diphenol compound having the structure:
wherein R 1 is selected from the group consisting of —CH═CH—, (—CH 2 —) a , and
in which a has a value from zero to eight, inclusive, and L 1 and L 2 are independently selected from the group consisting of hydrogen and straight and branched alkyl and alkylaryl groups containing up to 18 carbon atoms, provided that L 1 and L 2 are not both hydrogen;
b independently has a value between zero and eight, inclusive; and
R 2 is selected from the group consisting of straight and branched alkyl and alkyl-aryl groups containing up to 18 carbon atoms and at least one ether linkage; and
R 1 and (—CH 2 —) b of said tyrosine-derived diphenol compound is ring-substituted para to phenolic oxygens.
2. The diphenol of claim 1 , wherein R 1 is —CH 2 —CH 2 —, b is one and R 2 contains at least one ether linkage.
3. The diphenol of claim 2 , wherein R 2 is —CH 2 —CH 2 —O—CH 2 —CH 2 —O—CH 2 —CH 2 —OH.
4. A condensation polymer made from the diphenol of claim 1 .
5. The condensation polymer of claim 4 , wherein R 1 of said diphenol is —CH 2 —CH 2 — and b is one.
6. A cell growth substrate comprising at least one polymer surface consisting essentially of the condensation polymer of claim 4 .
7. The cell growth substrate according to claim 6 in the form of a solvent cast or compression molded film.
8. A drug release article comprising the condensation polymer of claim 4 .
9. The article according to claim 8 in the form of a solvent cast film, a compression molded film or an extruded rod or ribbon.