Methods of treating autism spectrum disorders and compositions for same
Disclosed are compositions that inhibit brain blood vessel leakage, compositions for treating autism spectrum disorders, methods of treating autism spectrum disorders, and methods of screening for an autism spectrum disorder.
1. A method of treating an autism spectrum disorder, comprising administering to a subject in need thereof an effective amount of a composition comprising one or more flavonoids, wherein the one or more flavonoids are present in an amount of 10-3,000 mg per tablet or capsule and the flavonoids comprise luteolin, and optionally, a serotonin blocker, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antipsychotic agent, a heavy metal chelator, and olive kernel extract and, wherein the composition inhibits brain blood vessel leakage.
2. The method of claim 1 , wherein the autism spectrum disorder is autism.
3. The method of claim 1 , wherein the autism spectrum disorder is Asperger's disorder.
4. The method of claim 1 , wherein the autism spectrum disorder is Rett syndrome.
5. The method of claim 1 , wherein one of the one or more flavonoids is apigenin, astragaline, (−)-epigallocatechin-3 gallate, genistein, hesperetin, hesperidin, kaempferol, myricetin, quercetin, or rutin.
6. The method of claim 1 , wherein the serotonin blocker is azatadine or cyproheptadine.
7. The method of claim 1 , wherein the histamine-1 receptor antagonist is azelastine, azatadine, hydroxyzine, merelastine, or rupatadine.
8. The method of claim 1 , wherein the histamine-3 receptor agonist is R(−)-α-methyl histamine, N α -methyl histamine, N τ -methyl histamine, α-N α -dethylhistamine, α,β-dimethyl histamine, N α -methyl-α-(dimethyl)histamine, N α -methyl-α-(chloromethyl)histamine, or α,β-difluoro-N α -(fluoromethyl)histamine.
9. The method of claim 1 wherein the antipsychotic agent is risperidone.
10. The method of claim 1 wherein the heavy metal chelator is meso-2,3-dimercaptosuccinic acid.
11. The method of claim 1 , wherein the composition is administered by oral or parenteral routes.
12. A method of treating an autism spectrum disorder, comprising administering to a subject in need thereof an effective amount of a composition comprising one or more flavonoids, wherein the one or more flavonoids are present in an amount of 10-3,000 mg per tablet or capsule and the flavonoids comprise luteolin and optionally, a serotonin blocker, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antipsychotic agent, a heavy metal chelator, and olive kernel extract.
13. The method of claim 12 , wherein the autism spectrum disorder is autism.
14. The method of claim 12 , wherein the composition further comprises one or more of apigenin, astragaline, (−)-epigallocatechin-3 gallate, genistein, hesperetin, hesperidin, kaempferol, or myricetin.
15. The method of claim 12 , wherein the composition inhibits brain blood vessel leakage.