Spiro-piperidine inhibitors
View Patent ↗Provided are compounds that are capable of modulating the activity of the influenza A virus via interaction with the M2 transmembrane protein. Also provided are methods for treating an influenza A-affected disease state or infection comprising administering a composition comprising one or more compounds that have been identified as being capable of interaction with the M2 protein.
1. A method for treating infection by influenza A virus or an influenza A virus-affected disease state comprising the step of administering to a subject in need thereof a composition comprising a compound of formula (I):
wherein
R 1 is hydrogen, alkyl, aralkyl, cycloalkyl-alkyl
a 1 is —CH 2 —;
R 2 and R 3 are each independently C 2 -C 4 alkyl,
or,
R 2 and R 3 taken together along with the carbon atom to which they are both attached form a 6 membered carbocyclic ring
or a stereoisomer or pharmaceutically acceptable salt thereof.
2. The method according to claim 1 wherein said influenza A virus-affected disease state or infection comprises influenza (flu).
3. The method according to claim 1 wherein said influenza A virus-affected disease state or infection comprises one or more of pneumonia, bronchitis, sinus infection, and ear infection.
4. The method according to claim 1 said composition additionally comprises a pharmaceutically acceptable carrier, diluent, or excipient.
5. The method according to claim 1 wherein said influenza A virus is a wild-type virus.
6. The method according to claim 1 wherein said influenza A virus is a mutant.
7. The method according to claim 1 wherein R 2 and R 3 taken together along with the carbon atom to which they are both attached form cyclohexane.
8. The method according to claim 1 wherein R 1 is hydrogen, and R 2 and R 3 are each C 2 -C 4 alkyl.