18-membered macrocycles and analogs thereof
View Patent ↗The present invention relates generally to the 18-membered macrocyclic antimicrobial agents called Tiacumicins, specifically, OPT-80 (which is composed almost entirely of the R-Tiacumicin B), pharmaceutical compositions comprising OPT-80, and methods using OPT-80. In particular, this compound is a potent drug for the treatment of bacterial infections, specifically C. difficile infections.
1. An isolated compound having the formula:
free from other stereoisomers of the compound.
2. A pharmaceutical composition comprising the compound of claim 1 or pharmaceutically acceptable salt thereof.
3. The pharmaceutical composition of claim 2 , further comprising one or more pharmaceutically acceptable carriers.
4. The pharmaceutical composition of claim 3 , wherein the composition is formulated for oral administration.
5. The pharmaceutical composition of claim 4 , wherein the composition is formulated as a tablet.
6. A pharmaceutical composition consisting of the compound of claim 1 or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers.