Heat shock protein 90 inhibitors

1. Compound of the Formula III:

wherein A is hydrogen, halogen, lower alkyl, lower alkoxy, aryl, aralyl, allyl, or together with B and the atoms to which they are attached together form a heterocyclic ring having 4 to 12 ring members with at least one heteroatom selected from oxygen, nitrogen, or sulfur;

wherein B is hydroxy, amino, halogen, lower alkoxy, aralkoxy, or together with A and the atoms to which they are attached together form a heterocyclic ring having 4 to 12 ring members with at least one heteroatom selected from oxygen, nitrogen, or sulfur;

wherein C is hydroxy, amino, or lower alkoxy;

wherein D is alkyl, amino, oxygen, sulfanyl, sulfenyl, sulfonyl, or together with K and the carbon atoms to which they are attached form a carbocyclic ring or heterocyclic ring having 5 to 8 ring members; or D is alkyl and together with K and the carbon atoms to which they are attached form a carbocyclic ring or heterocyclic ring having 5 to 8 ring members;

wherein E is hydroxy, halogen, lower alkoxy, amino, allyl amine;

wherein F is hydroxy, halogen, thiol, lower alkoxy, amino, or is oxidized to form a ketone;

wherein G is hydrogen, hydroxy, halogen, amino, thiol, lower alkyl, lower alkoxy, or is oxidized to form a ketone;

wherein I is hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, thiol, amino, nitro, ester, or an amide comprising —NHCOR 1 and wherein is R 1 is hydrogen, lower alkyl, or lower alkoxy;

wherein K is alkyl, cycloalkyl, or together with D and the carbon atoms to which they are attached form a carbocyclic ring or heterocyclic ring having 5 to 8 ring members; and

wherein R is hydrogen or alkyl.

2. The compound according to claim 1 , corresponding to Formula III(A):

wherein A is hydrogen, chlorine, fluorine, methoxy, ethoxy, phenyl, benzyl, or allyl;

wherein B is hydroxy, chlorine, fluorine, methoxy, ethoxy, or benzoxy;

wherein C is hydroxy, amino, methoxy, or ethoxy;

wherein D is oxygen, alkyl, or —NH—;

wherein E is hydroxy, chlorine, fluorine, methoxy, ethoxy, or —NH 2 ;

wherein F is hydroxy, chlorine, fluorine, thiol, methoxy, ethoxy, amino, or is oxidized to form a ketone;

wherein G is hydroxy, chlorine, fluorine, —NH 2 , thiol, methoxy, ethoxy, or is oxidized to form ketone; and

wherein R 1 is hydrogen, lower alkyl, or lower alkoxy.

3. The compound according to claim 1 , corresponding to Formula III(C):

wherein A is hydrogen, chlorine, fluorine, methoxy, ethoxy, phenyl, benzyl, or allyl;

wherein B is hydroxy, chlorine, fluorine, methoxy, ethoxy, or benzoxy;

wherein C is hydroxy, amino, methoxy, or ethoxy;

wherein E is hydroxy, chlorine, fluorine, methoxy, ethoxy, or amino;

wherein F is hydroxy, chlorine, fluorine, thiol, methoxy, ethoxy, amino, or oxidized to form a ketone;

wherein G is hydroxy, chlorine, fluorine, thiol, methoxy, ethoxy, amino, or is oxidized to form a ketone; and

wherein is R 1 is hydrogen, lower alkyl, or lower alkoxy.

4. The compound according to claim 1 , corresponding to Formula III(D):

wherein A and B together with the atoms to which they are attached together form a heterocyclic ring having 4 to 10 ring members with at least one heteroatom selected from oxygen, nitrogen, or sulfur;

wherein C is hydroxy, amino, methoxy, or ethoxy;

wherein D is —CH 2 —, —NH—, oxygen, sulfanyl, sulfenyl, or sulfonyl;

wherein E is chlorine, fluorine, hydroxy, methoxy, ethoxy, or amino;

wherein F is hydroxy, chlorine, fluorine, thiol, methoxy, ethoxy, amino, or is oxidized to from a ketone; and

wherein G is hydroxy, chlorine, fluorine, amino, thiol, methoxy, ethoxy, or is oxidized to form a ketone; and

wherein I is hydrogen, hydroxy, chlorine, fluorine, methyl, methoxy, ethoxy, or amino.

5. The compound according to claim 1 , corresponding to Formula III(F):

wherein A is hydrogen, chlorine, fluorine, methoxy, ethoxy, phenyl, benzyl, or allyl;

wherein B is hydroxy, chlorine, fluorine, methoxy, ethoxy, or benzoxy;

wherein C is hydroxy, amino, methoxy, or ethoxy;

wherein D is lower alkyl, oxygen, or —NH—;

wherein E is hydroxy, chlorine, fluorine, methoxy, ethoxy, or —NH 2 ;

wherein F is hydroxy, chlorine, fluorine, thiol, methoxy, ethoxy, amino, or is oxidized to form a ketone;

wherein G is hydroxy, chlorine, fluorine, amino, thiol, methoxy, ethoxy, or is oxidized to form a ketone; and

wherein I is hydrogen, hydroxy, chlorine, fluorine, methyl, methoxy, ethoxy, or amino.

6. The compound according to claim 1 , corresponding to the Formula III:

wherein A is hydrogen, halogen, lower alkyl, lower alkoxy, aryl, aralyl, allyl, or together with B and the atoms to which they are attached together form a heterocyclic ring having 4 to 12 ring members with at least one heteroatom selected from oxygen, nitrogen, or sulfur;

wherein B is hydroxy, amino, halogen, lower alkoxy, aralkoxy, or together with A and the atoms to which they are attached together form a heterocyclic ring having 4 to 12 ring members with at least one heteroatom selected from oxygen, nitrogen, or sulfur;

wherein C is hydroxy, amino, or lower alkoxy;

wherein D is alkyl, amino, oxygen, sulfanyl, sulfenyl, sulfonyl, or together with K and the carbon atoms to which they are attached form a carbocyclic ring or heterocyclic ring having 5 to 8 ring members; or D is alkyl and together with K and the carbon atoms to which they are attached form a carbocyclic ring or heterocyclic ring having 5 to 8 ring members;

wherein E is hydroxy, halogen, lower alkoxy, amino, allyl amine;

wherein F is hydroxy, or is oxidized to form a ketone;

wherein G is hydroxy, or is oxidized to form a ketone;

wherein I is hydrogen, hydroxy, halogen, lower alkyl, lower alkoxy, thiol, amino, ester, or an amide comprising —NHCOR 1 and wherein is R 1 is hydrogen, lower alkyl, or lower alkoxy;

wherein K is alkyl, cycloalkyl, or together with D and the carbon atoms to which they are attached form a carbocyclic ring or heterocyclic ring having 5 to 8 ring members; and

wherein R is hydrogen or alkyl.

7. The compound according to claim 6 , wherein

A is halogen;

B is hydroxy;

C is hydroxy; and

D is oxygen.

8. The compound according to claim 7 , wherein

I is an amide comprising —NHCOR 1 and wherein is R 1 is hydrogen, lower alkyl, or lower alkoxy.

9. The compound according to claim 8 , wherein

E is lower alkoxy.