Use of diindolylmethane (DIM) compounds and derivatives as neuroprotective agents
View Patent ↗Presented herein are diindolylmethane derivative compounds useful for the prevention and or treatment of neurological conditions, including neurological conditions related to neuroinflammation. One such neurological condition is Parkinson's disease.
1. A method for treating Parkinson's disease in a subject, comprising administering to the subject a therapeutically effective amount of a composition comprising a compound selected from the group consisting of: 1,1-bis(3′-indolyl)-1-(p-chlorophenyl)methane, 1,1-bis(3′-indolyl)-1-(p-methoxyphenyl)methane, 1,1-bis(3′-indolyl)-1-(p-bromophenyl)methane, and 1,1-bis(3′-indolyl)-1-(p-fluorophenyl)methane,
or a pharmaceutically acceptable salt or stereoisomer thereof.
2. The method of claim 1 , wherein the compound comprises 1,1-bis(3′-indolyl)-1-(p-chlorophenyl)methane, or a pharmaceutically acceptable salt or stereoisomer thereof.
3. The method of claim 1 , wherein the compound comprises 1,1-bis(3′-indolyl)-1-(p-methoxyphenyl)methane, or a pharmaceutically acceptable salt or stereoisomer thereof.
4. The method of claim 1 , wherein the compound comprises 1,1-bis(3′-indolyl)-1-(p-bromophenyl)methane, or a pharmaceutically acceptable salt or stereoisomer thereof.
5. The method of claim 1 , wherein the compound comprises 1,1-bis(3′-indolyl)-1-(p-fluorophenyl)methane, or a pharmaceutically acceptable salt or stereoisomer thereof.