Selectively-Releasable Adhesives That Include A Glycosominoglycan
In one embodiment, a selectively-releasable adhesive includes a copolymer formed from a multifunctional alcohol, a multifunctional carboxylic acid, and a glycosaminoglycan (GAG). In one embodiment, an adhesive article includes a backing material having a surface and a layer of adhesive provided on the surface, the adhesive layer having an outer surface opposite to a surface that contacts the backing material, the outer surface being at least partly composed of a copolymer formed from a multifunctional alcohol, a multifunctional carboxylic acid, and a glycosaminoglycan (GAG).
1 . A selectively-releasable adhesive comprising:
a copolymer formed from:
a multifunctional alcohol,
a multifunctional carboxylic acid, and
a glycosaminoglycan (GAG).
2 . The selectively-releasable adhesive of claim 1 , wherein the multifunctional alcohol comprises one or more of glycerol, a monomeric carbohydrate, and a small polyol.
3 . The selectively-releasable adhesive of claim 1 , wherein the multifunctional alcohol comprises glycerol.
4 . The selectively-releasable adhesive of claim 1 , wherein the multifunctional carboxylic acid comprises one or more of a diacid and a triacid.
5 . The selectively-releasable adhesive of claim 1 , wherein the multifunctional carboxylic acid comprises decanedioic acid.
6 . The selectively-releasable adhesive of claim 1 , wherein the a glycosaminoglycan (GAG) comprises one or more of chondroitin sulfate, dermatan sulfate, keratan sulfate, heparin, heparin sulfate, and hyaluronic acid.
7 . The selectively-releasable adhesive of claim 1 , wherein the glycosaminoglycan (GAG) comprises hyaluronic acid.
8 . The selectively-releasable adhesive of claim 1 , wherein the multifunctional alcohol comprises glycerol, the multifunctional carboxylic acid comprises decanedioic acid, the glycosaminoglycan (GAG) comprises hyaluronic acid, and the adhesive comprises poly(diglyceryl decanedioate)-co-hyaluronan (PDDH).
9 . A method for making an adhesive article, the method comprising:
coating a substrate with a release agent;
applying an adhesive solution to the coated substrate;
curing the adhesive solution in place on the coated substrate to form a cured adhesive layer;
applying a backing material to the cured adhesive layer; and
removing the backing material along with the cured adhesive layer from the substrate to obtain an adhesive article.
10 . The method of claim 9 , wherein coating a substrate comprises coating the substrate with a glycosaminoglycan (GAG) solution.
11 . The method of claim 9 , wherein coating a substrate comprises coating the substrate with a hyaluronic acid solution.
12 . The method of claim 9 , wherein applying an adhesive solution comprises applying a selectively-releasable adhesive solution to the coated substrate.
13 . The method of claim 9 , wherein the adhesive solution comprises a copolymer formed from a multifunctional alcohol and a multifunctional carboxylic acid.
14 . The method of claim 9 , wherein the adhesive solution comprises poly(diglyceryl decanedioate) (PDD).
15 . The method of claim 9 , wherein curing the adhesive solution comprises heating the adhesive solution in an oven.
16 . The method of claim 9 , wherein curing comprises curing the adhesive solution the equivalent of approximately 6 to 12 hours at approximately 120° C. and 100 milliTorr.
17 . The method of claim 9 , wherein curing comprises curing the adhesive solution the equivalent of approximately 8 to 10 hours at approximately 120° C. and 100 milliTorr.
18 . The method of claim 9 , wherein curing comprises curing the adhesive solution the equivalent of approximately 9 hours at approximately 120° C. and 100 milliTorr.
19 . The method of claim 9 , wherein applying a backing material comprises applying a cellulosic backing material to the adhesive layer.
20 . The method of claim 9 , wherein applying a backing material comprises applying a polymeric backing material to the adhesive layer.
21 . The method of claim 9 , further comprising rinsing the substrate with water or an aqueous solution prior to removing the backing material and the cured adhesive layer from the substrate.
22 . A method for making an adhesive article, the method comprising:
synthesizing a poly(diglyceryl decanedioate) (PDD) prepolymer solution;
coating a substrate with a glycosaminoglycan (GAG) solution;
applying the poly(diglyceryl decanedioate) (PDD) prepolymer solution to the coated substrate;
curing the poly(diglyceryl decanedioate) (PDD) prepolymer solution in place on the coated substrate to form an adhesive layer that comprises poly(diglyceryl decanedioate)-co-hyaluronan (PDDH);
applying a backing material to the adhesive layer;
rinsing the backing material, adhesive layer, and substrate to dissolve at least some of the GAG solution; and
removing the backing material along with the adhesive layer from the substrate to obtain an adhesive article.
23 . An adhesive article comprising:
a backing material having a surface;
a layer of adhesive provided on the surface of the backing material, the adhesive layer having an outer surface opposite to a surface that contacts the backing material, the outer surface being at least partly composed of a copolymer formed from a multifunctional alcohol, a multifunctional carboxylic acid, and a glycosaminoglycan (GAG).
24 . The article of claim 23 , wherein the backing material is a fabric.
25 . The article of claim 23 , wherein the backing material is a film.
26 . The article of claim 23 , wherein the backing material comprises a cellulosic material.
27 . The article of claim 23 , wherein the backing material comprises a polymeric material.
28 . The article of claim 23 , wherein the adhesive layer comprises poly(diglyceryl decanedioate)-co-hyaluronan (PDDH).
29 . The article of claim 23 , wherein the glycosaminoglycan (GAG) is hyaluronic acid.
30 . The article of claim 23 , wherein the article is adhesive tape.
31 . The article of claim 23 , wherein the article is an adhesive dressing.