Toxin-eating bacteria and bioremediation
Methods are provided for reducing a level of one or more antibiotics from an antibiotic-contaminated substance. An organism that can utilize the one or more antibiotics as a carbon source is cultured in the presence of the antibiotic-contaminated substance for a sufficient amount of time to reduce the level of one or more antibiotics from the antibiotic-contaminated substance.
1. A method of reducing a level of one or more antibiotics from an antibiotic-contaminated substance comprising culturing a bacterium that can utilize the one or more antibiotics as a carbon source in the presence of the antibiotic-contaminated substance for a sufficient amount of time to reduce the level of one or more antibiotics from the antibiotic-contaminated substance wherein the one or more antibiotics is a sulfonamide, quinolone, glycopeptide, amphenicol, or aminoglycoside.
2. The method of claim 1 , wherein the antibiotic-contaminated substance is selected from the group consisting of contaminated soil, contaminated water and a contaminated work surface.
3. The method of claim 2 , wherein the contaminated work surface is present in a hospital, a clinic or a laboratory.
4. The method of claim 1 , wherein the one or more antibiotics are used by the bacterium as a sole carbon source.
5. The method of claim 1 , wherein the bacterium has a 16S nucleic acid sequence comprising a GenBank Accession Number selected from the group consisting of EU515334, EU515335, EU515336, EU515337, EU515338, EU515339, EU515400, EU515401, EU515402, EU515403, EU515404, EU515405, EU515406, EU515407, EU515408, EU515409, EU515410, EU515411, EU515412, EU515413, EU515414, EU515415, EU515416, EU515417, EU515418, EU515419, EU515420, EU515421, EU515422, EU515423, EU515424, EU515425, EU515426, EU515427, EU515428, EU515429, EU515430, EU515431, EU515432, EU515433, EU515434, EU515435, EU515436, EU515437, EU515438, EU515439, EU515440, EU515441, EU515442, EU515443, EU515444, EU515445, EU515446, EU515447, EU515448, EU515449, EU515450, EU515451, EU515452, EU515453, EU515454, EU515455, EU515456, EU515457, EU515458, EU515459, EU515460, EU515461, EU515462, EU515463, EU515464, EU515465, EU515466, EU515467, EU515468, EU515469 EU515470, EU515471, EU515472, EU515473, EU515474, EU515475, EU515476, EU515477, EU515478, EU515479, EU515480, EU515481, EU515482, EU515483, EU515484, EU515485, EU515486, EU515487, EU515488, EU515489, EU515490, EU515491, EU515492, EU515493, EU515494, EU515495, EU515496, EU515497, EU515498, EU515499, EU515500, EU515501, EU515502, EU515503, EU515504, EU515505, EU515506, EU515507, EU515508, EU515509, EU515510, EU515511, EU515512, EU515513, EU515514, EU515515, EU515516, EU515517, EU515518, EU515519, EU515520, EU515521, EU515522, EU515523, EU515524, EU515525, EU515526, EU515527, EU515528, EU515529, EU515530, EU515531, EU515532, EU515533, EU515534, EU515535, EU515536, EU515537, EU515538, EU515539, EU515540, EU515541, EU515542, EU515543, EU515544, EU515545, EU515546, EU515547, EU515548, EU515549, EU515550, EU515551, EU515552, EU515553, EU515554, EU515555, EU515556, EU515557, EU515558, EU515559, EU515560, EU515561, EU515562, EU515563, EU515564, EU515565, EU515566, EU515567, EU515568, EU515569, EU515570, EU515571, EU515572, EU515573, EU515574, EU515575, EU515576, EU515577, EU515578, EU515579, EU515580, EU515581, EU515582, EU515583, EU515584, EU515585, EU515586, EU515587, EU515588, EU515589, EU515590, EU515591, EU515592, EU515593, EU515594, EU515595, EU515596, EU515597, EU515598, EU515599, EU515600, EU515601, EU515602, EU515603, EU515604, EU515605, EU515606, EU515607, EU515608, EU515609, EU515610, EU515611, EU515612, EU515613, EU515614, EU515615, EU515616, EU515617, EU515618, EU515619, EU515620, EU515621, EU515622 and EU515623.
6. A method of reducing a level of one or more antibiotic from an antibiotic-contaminted substance comprising culture a bacterium that can utilize the one or more antibiotics as a carbon source in the presence of the antibiotic-contaminated substance for a sufficient amount of time to reduce the level of one or more antibiotics from the antibiotic-contaminated substance, wherein the one or more antibiotics is chloramphenicol, vancomycin, carbenicillin, ciprofloxacin, mafenide, kanamycin, sisomicin, amikacin, trimethropin, D-cycloserine, gentamicin, dicloxacillin, nalidixic acid, thiamphenicol, levofloxacin, sulfemethizole or sulfisoxazole.
7. The method of claim 6 , wherein the bacterium has a 16S nucleic acid sequence comprising a GenBank Accession Number selected from the group consisting of EU515334, EU515335, EU515336, EU515337, EU515338, EU515339, EU515400, EU515401, EU515402, EU515403, EU515404, EU515405, EU515406, EU515407, EU515408, EU515409, EU515410, EU515411, EU515412, EU515413, EU515414, EU515415, EU515416, EU515417, EU515418, EU515419, EU515420, EU515421, EU515422, EU515423, EU515424, EU515425, EU515426, EU515427, EU515428, EU515429, EU515430, EU515431, EU515432, EU515433, EU515434, EU515435, EU515436, EU515437, EU515438, EU515439, EU515440, EU515441, EU515442, EU515443, EU515444, EU515445, EU515446, EU515447, EU515448, EU515449, EU515450, EU515451, EU515452, EU515453, EU515454, EU515455, EU515456, EU515457, EU515458, EU515459, EU515460, EU515461, EU515462, EU515463, EU515464, EU515465, EU515466, EU515467, EU515468, EU515469 EU515470, EU515471, EU515472, EU515473, EU515474, EU515475, EU515476, EU515477, EU515478, EU515479, EU515480, EU515481, EU515482, EU515483, EU515484, EU515485, EU515486, EU515487, EU515488, EU515489, EU515490, EU515491, EU515492, EU515493, EU515494, EU515495, EU515496, EU515497, EU515498, EU515499, EU515500, EU515501, EU515502, EU515503, EU515504, EU515505, EU515506, EU515507, EU515508, EU515509, EU515510, EU515511, EU515512, EU515513, EU515514, EU515515, EU515516, EU515517, EU515518, EU515519, EU515520, EU515521, EU515522, EU515523, EU515524, EU515525, EU515526, EU515527, EU515528, EU515529, EU515530, EU515531, EU515532, EU515533, EU515534, EU515535, EU515536, EU515537, EU515538, EU515539, EU515540, EU515541, EU515542, EU515543, EU515544, EU515545, EU515546, EU515547, EU515548, EU515549, EU515550, EU515551, EU515552, EU515553, EU515554, EU515555, EU515556, EU515557, EU515558, EU515559, EU515560, EU515561, EU515562, EU515563, EU515564, EU515565, EU515566, EU515567, EU515568, EU515569, EU515570, EU515571, EU515572, EU515573, EU515574, EU515575, EU515576, EU515577, EU515578, EU515579, EU515580, EU515581, EU515582, EU515583, EU515584, EU515585, EU515586, EU515587, EU515588, EU515589, EU515590, EU515591, EU515592, EU515593, EU515594, EU515595, EU515596, EU515597, EU515598, EU515599, EU515600, EU515601, EU515602, EU515603, EU515604, EU515605, EU515606, EU515607, EU515608, EU515609, EU515610, EU515611, EU515612, EU515613, EU515614, EU515615, EU515616, EU515617, EU515618, EU515619, EU515620, EU515621, EU515622 and EU515623.
8. A method of eliminating one or more antibiotics from an antibiotic-contaminated substance, comprising culturing a bacterium in the presence of the antibiotic-contaminated substance for a sufficient amount of time to eliminate the one or more antibiotics from the antibiotic-contaminated substance wherein the one or more antibiotics is a sulfonamide, quinolone, glycopeptide, amphenicol, or aminoglycoside and wherein the bacterium has a 16S nucleic acid sequence comprising a GenBank Accession Number selected from the group consisting of EU515334, EU515335, EU515336, EU515337, EU515338, EU515339, EU515400, EU515401, EU515402, EU515403, EU515404, EU515405, EU515406, EU515407, EU515408, EU515409, EU515410, EU515411, EU515412, EU515413, EU515414, EU515415, EU515416, EU515417, EU515418, EU515419, EU515420, EU515421, EU515422, EU515423, EU515424, EU515425, EU515426, EU515427, EU515428, EU515429, EU515430, EU515431, EU515432, EU515433, EU515434, EU515435, EU515436, EU515437, EU515438, EU515439, EU515440, EU515441, EU515442, EU515443, EU515444, EU515445, EU515446, EU515447, EU515448, EU515449, EU515450, EU515451, EU515452, EU515453, EU515454, EU515455, EU515456, EU515457, EU515458, EU515459, EU515460, EU515461, EU515462, EU515463, EU515464, EU515465, EU515466, EU515467, EU515468, EU515469 EU515470, EU515471, EU515472, EU515473, EU515474, EU515475, EU515476, EU515477, EU515478, EU515479, EU515480, EU515481, EU515482, EU515483, EU515484, EU515485, EU515486, EU515487, EU515488, EU515489, EU515490, EU515491, EU515492, EU515493, EU515494, EU515495, EU515496, EU515497, EU515498, EU515499, EU515500, EU515501, EU515502, EU515503, EU515504, EU515505, EU515506, EU515507, EU515508, EU515509, EU515510, EU515511, EU515512, EU515513, EU515514, EU515515, EU515516, EU515517, EU515518, EU515519, EU515520, EU515521, EU515522, EU515523, EU515524, EU515525, EU515526, EU515527, EU515528, EU515529, EU515530, EU515531, EU515532, EU515533, EU515534, EU515535, EU515536, EU515537, EU515538, EU515539, EU515540, EU515541, EU515542, EU515543, EU515544, EU515545, EU515546, EU515547, EU515548, EU515549, EU515550, EU515551, EU515552, EU515553, EU515554, EU515555, EU515556, EU515557, EU515558, EU515559, EU515560, EU515561, EU515562, EU515563, EU515564, EU515565, EU515566, EU515567, EU515568, EU515569, EU515570, EU515571, EU515572, EU515573, EU515574, EU515575, EU515576, EU515577, EU515578, EU515579, EU515580, EU515581, EU515582, EU515583, EU515584, EU515585, EU515586, EU515587, EU515588, EU515589, EU515590, EU515591, EU515592, EU515593, EU515594, EU515595, EU515596, EU515597, EU515598, EU515599, EU515600, EU515601, EU515602, EU515603, EU515604, EU515605, EU515606, EU515607, EU515608, EU515609, EU515610, EU515611, EU515612, EU515613, EU515614, EU515615, EU515616, EU515617, EU515618, EU515619, EU515620, EU515621, EU515622 and EU515623.
9. The method of claim 8 , wherein the one or more antibiotics are used by the bacterium as a sole carbon source.
10. The method of claim 8 , wherein the antibiotic-contaminated substance is selected from the group consisting of contaminated soil, contaminated water and a contaminated work surface.
11. The method of claim 10 , wherein the contaminated work surface is present in a hospital, a clinic or a laboratory.
12. A method of eliminating one or more antibiotics from an antibiotic-contaminated substance, comprising culturing a bacterium in the presence of the antibiotic-contaminated substance for a sufficient amount of time to eliminate the one or more antibiotics from the antibiotic-contaminated substance wherein the one or more antibiotics are selected from the group consisting of chloramphenicol, vancomycin, carbenicillin, ciprofloxacin, mafenide, kanamycin, sisomicin, amikacin, trimethropin, D-cycloserine, gentamicin, dicloxacillin, nalidixic acid, thiamphenicol, levofloxacin, sulfamethizole and sulfisoxazole.