Iodo-hexose compounds useful to treat cancer
View Patent ↗Methods of treating glioblastoma and pancreatic cancer are provided by the administration of a therapeutically effective amount of a iodo-hexose compound to a subject in need thereof. The subject disclosure includes methods of treating glioblastoma and pancreatic cancer comprising the administration of a therapeutically effective amount of a 2-deoxy-2-iodo-D-hexose compound including 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-glucose, 2-deoxy-2-iodo-D-galactose, and/or 2-deoxy-2-iodo-D-talose to a subject in need thereof.
1. A pharmaceutical composition comprising an iodo-hexose compound having the structural formula:
2. A composition comprising an iodo-hexose compound having the structural formula:
3. A method of treating glioblastoma or pancreatic cancer comprising the administration, to a patient in need thereof, of a therapeutically effective amount of at least one 2-deoxy-2-iodo-D hexose compound selected from the group consisting of 2-deoxy-2-iodo-D-mannose, 2-deoxy-2-iodo-D-talose, and 2-deoxy-2-iodo-D-galactose.
4. The method of claim 3 wherein the 2-deoxy-2-iodo-D-hexose compound is 2-deoxy-2-iodo-D-mannose.
5. The method of claim 3 wherein the 2-deoxy-2-iodo-D-hexose compound is 2-deoxy-2-iodo-D-talose.
6. The method of claim 3 wherein the 2-deoxy-2-iodo-D-hexose compound is 2-deoxy-2-iodo-D-galactose.
7. A method for achieving an effect in a patient comprising the administration of a therapeutically effective amount of at least one iodo-hexose compound selected from the group consisting of 2-deoxv-2-iodo-D-mannose, 2-deoxy-2-iodo-D-galactose, and 2-deoxy-2-iodo-D-talose, wherein the effect is reducing tumor growth resulting from at least one disease selected from the group consisting of pancreatic cancer and glioblastoma.