Perfluorocarbon gel formulations
A perfluorocarbon gel composition is disclosed with numerous uses including topical medical and cosmetic uses.
1. A perfluorocarbon gel composition comprising 84-90 wt % perfluorocarbon and 8-11 wt % water and 2-4 wt % surfactants relative to the total weight of the gel, wherein the perfluorocarbon is perfluoro(tert-butylcyclohexane).
2. The perfluorocarbon gel composition of claim 1 , wherein the surfactants include polyoxyethylene-polyoxypropylene block copolymers.
3. The perfluorocarbon gel composition of claim 2 , wherein the polyoxyethylene-polyoxypropylene block copolymers include Poloxamer 105 and/or Poloxamer 188.
4. The perfluorocarbon gel composition of claim 1 , wherein the composition further comprises 0.01-6 wt % Vitamin E.
5. The perfluorocarbon gel composition of claim 4 , wherein the composition comprises 0.03 wt % Vitamin E.
6. The perfluorocarbon gel composition of claim 1 , wherein the composition further comprises 0.02-3.20 wt % preservatives.
7. The perfluorocarbon gel composition of claim 1 , wherein the composition comprises 90 wt % perfluorocarbon, 8 wt % water, and 2 wt % surfactants.
8. The perfluorocarbon gel composition of claim 1 , wherein the composition comprises 86.86 wt % perfluorocarbon, 10.42 wt % water, 2.69 wt % surfactants and 0.03 wt % Vitamin E.
9. The perfluorocarbon gel composition of claim 8 , wherein the composition comprises 86.86 wt % perfluoro(tert-butylcyclohexane), 10.42 wt % water, 2.43 wt % Poloxamer 105, 0.26 Wt % Poloxamer 188 and 0.03 wt % Vitamin E.
10. The perfluorocarbon gel composition of claim 1 , characterized by that it continuously delivers oxygen to a tissue at a rate of 0.2 cc/hour −20.0 cc/hour for up to 24 hours.
11. The perfluorocarbon gel composition of claim 10 , wherein the composition continuously delivers oxygen to the tissue at a rate of 2.0 cc/hour for 24 hours.
12. The perfluorocarbon gel composition of claim 1 , further comprising urea hydrogen peroxide.
13. A process of manufacturing the perfluorocarbon gel composition of claim 1 comprising the steps:
a) mixing water and surfactants—as an aqueous phase in a vessel;
b) homogenizing the mixture;
c) adding perfluorocarbon to the mixture over time during high speed homogenization; and
d) obtaining the gel.
14. The process of claim 13 , wherein in step a) the aqueous phase include distilled water, as said water, surfactants, and further optionally, preservatives.
15. The process of claim 13 , wherein in step a) the vessel is a glass, polyethylene, PET, or stainless steel vessel.
16. The process of claim 13 , wherein in step b) the homogenizer is a rotor stator homogenizer.
17. The process of claim 13 , wherein in step b) the mixture is homogenized for 4-6 minutes.
18. The process of claim 17 , wherein step b) the mixture is homogenized for 5 minutes.
19. The process of claim 13 , wherein in step b) the mixture is homogenized at 10,000-35,000 RPM.
20. The process of claim 13 , wherein in step c) the perfluorocarbon is added in aliquots or continuously over 10-30 minutes.
21. The perfluorocarbon gel composition of claim 1 , comprising 84-90 wt % perfluorocarbon, 9-11 wt % water, and 2-4 wt % surfactants, and 0.02-3.20 wt % preservatives relative to the total weight of the gel.
22. The perfluorocarbon gel composition of claim 21 , wherein the surfactants are polyoxyethylene-polyoxypropylene block copolymers.
23. The perfluorocarbon gel composition of claim 22 , wherein the polyoxyethylene-polyoxypropylene block copolymers include Poloxamer 105.