Spiroindalones

1. A compound of formula Ia or a pharmaceutically acceptable salt thereof:

wherein A is selected from imidazole-2-yl, pyrrol-2-yl, and pyrid-2-yl;

the group

 is selected from 4-biphenyl, 3-quinolinyl, 6-(methoxycarbonyl)-2-naphthyl, 7-trifluoromethyl-3-quinolinyl, 2-naphthyl, 4-bromophenyl, 6,7-bis(cyano)-2-naphthyl, (3-methyl-4-phenyl)-phenyl, 4-(4-methoxyphenyl)phenyl, N-methyl-1,4-benzoxazin-7-yl, 4-(4-fluorophenyl)phenyl, 4-(1-pyrrolyl)phenyl, 4-(4-t-butylphenyl)phenyl, 2-(trifluoromethyl)-6-quinolinyl, 3-(trifluoromethyl)-7-isoquinolinyl, 3-(trifluoromethyl)-7-quinolinyl, 2-(trifluoromethyl)-6-quinoxalinyl, 2-(trifluoromethyl)-6-quinazolinyl, 2-oxo-6-benzoxazolinyl, 5-indolyl, pyrazolo[3,4-b]pyrid-5-yl, 3-chloro-7-cinnolinyl, 4-(3-pyridyl)phenyl, 4-(3-cyanophenyl)phenyl, 3-(phenyl)phenyl, 2-(cyclopropyl)-5-pyridyl, 6-chromonyl, 3,4-dimethylphenyl, 6-quinolinyl, 6-isoquinolinyl, 4-(phenoxy)phenyl, 7-(methoxy)-3-quinolinyl, 7-chloro-3-quinolinyl, 2-(1-pyrrolyl)-5-pyridyl, 2-methoxy-5-pyridyl, 2-hydroxy-5-pyridyl, 2-(dimethylamino)-5-pyridyl, and 1-naphthyl;

R 3 , R 4 and R 5 are independently selected from hydrogen, F, OH, C 1 -C 4 alkyl, C 1 -C 4 haloalkyl, and —OC 1 -C 4 alkyl;

R 6 , R 7 and R 8 are independently selected from hydrogen, halo, CN, and C 1 -C 6 alkyl optionally substituted with one to five fluorine atoms;

and R 9 , R 10 and R 11 are independently selected from hydrogen, halo, NH 2 , N(C 1 -C 6 alkyl) 2 , NO 2 , CN, N 3 , —OH, C 3 -C 10 cycloalkyl, C 2 -C 6 alkenyl, C 2 -C 6 alkynyl, —O-aryl, aryl-S(O) 0-2 , (C 0 -C 6 alkyl)S(O) 0-2 (C 0 -C 6 alkylene)-, (C 0 -C 6 alkyl)C(O)NH—, H 2 N—C(NH)—, (C 0 -C 6 alkyl)C(O)—, (C 0 -C 6 alkyl)OC(O)(C 0 -C 6 alkylene)-, C 0 -C 6 alkyl)O(C 1 -C 6 alkylene)-, (C 0 -C 6 alkyl)C(O) 1-2 (C 0 -C 6 alkylene)-, (C 0 -C 6 alkyl) 2 NC(O)—, (C 0 -C 6 alkyl)OC(O)NH—, aryl, aralkyl, heteroaryl, heteroaralkyl, C 1 -C 6 alkyl optionally substituted with one to five fluorine atoms, and —O(C 1 -C 6 alkyl) optionally substituted with one to five fluorine atoms.

2. A pharmaceutical composition comprising a compound of claim 1 and pharmaceutically acceptable carrier.

3. A compound according to claim 1 selected from:

1-biphenyl-4-yl-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-cyclopropylpyridin-2-yl)methyl]-1-quinolin-3-ylspiro[indole-3,4′-piperidin]-2(1H)-one;

1′-{[1-(pyridin-2-ylmethyl)-1H-pyrrol-2-yl]methyl}-1-quinolin-3-ylspiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-quinolin-3-ylspiro[indole-3,4′-piperidin]-2(1H)-one;

methyl {2-[(2-oxo-1-quinolin-3-yl-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl)methyl]-1H-imidazol-1-yl}acetate;

6-[1′-[(3-methylpyridin-2-yl)methyl]-2-oxospiro[indole-3,4′-piperidin]-1(2H)-yl]-2-naphthyl acetate;

methyl 6-[1′-[(3-methylpyridin-2-yl)methyl]-2-oxospiro[indole-3,4′-piperidin]-1(2H)-yl]-2-naphthoate;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-[7-(trifluoromethyl)quinolin-3-yl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-(2-naphthyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(4-bromophenyl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

6-[1′-[(3-methylpyridin-2-yl)methyl]-2-oxospiro[indole-3,4′-piperidin]-1(2H)-yl]naphthalene-2,3-dicarbonitrile;

1-(2-methylbiphenyl-4-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(4′-methoxybiphenyl-4-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one ;

1-(4′-fluorobiphenyl-4-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-[4-(1H-pyrrol-1-yl)phenyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(4′-tert-butylbiphenyl-4-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazo 1-2-yl)methyl]-1-[2-(trifluoromethyl)quinolin-6-yl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazo 1-2-yl)methyl]-1-[3-(trifluoromethyl)isoquinolin-7-yl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazo 1-2-yl)methyl]-1-[3-(trifluoromethyl)quinolin-7-yl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazo 1-2-yl)methyl]-1-[2-(trifluoromethyl)quinoxalin-6-yl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-[2-(trifluoromethyl)quinazolin-6-yl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-(2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl)spiro[indole-3,4′-piperidin]-2(1H)-one ;

1-(1H-indol-5-yl)-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-(1H-pyrazolo[3,4-b]pyridin-5-yl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(3-chlorocinnolin-7-yl)-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-(4-pyridin-3-ylphenyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

4′-[1′-[(3-methylpyridin-2-yl)methyl]-2-oxospiro[indole-3,4′-piperidin]-1(2H)-yl]biphenyl-3-carbonitrile;

1-biphenyl-3-yl-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(6-cyclopropylpyridin-3-yl)-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-(2-methyl-4-oxo-4H-chromen-6-yl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(3,4-dimethylphenyl)-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-quinolin-6-ylspiro[indole-3,4′-piperidin]-2(1H)-one;

1-isoquinolin-6-yl-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-(4-phenoxyphenyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(7-methoxyquinolin-3-yl)-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(7-chloroquinolin-3-yl)-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-[6-(1H-pyrrol-1-yl)pyridin-3-yl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(6-methoxypyridin-3-yl)-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(6-hydroxypyridin-3-yl)-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-[6-(dimethylamino)pyridin-3-yl]-1′-[(1-methyl-1H-imidazol-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-quinolin-3-ylspiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-methyl-1H-imidazol-2-yl)methyl]-1-(1-naphthyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-5-bromo-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

{2-[(2-oxo-1-quinolin-3-yl-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl)methyl]-1H-imidazol-1-yl}acetic acid;

1-biphenyl-4-yl-1′-[(3-methylpyridin-2-yl)methyl]-2-oxo-1,2-dihydrospiro[indole-3,4′-piperidine]-5-carbonitrile;

1′-[(3,5-dimethylpyridin-2-yl)methyl]-1-quinolin-3-ylspiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(1-benzyl-1H-imidazol-2-yl)methyl]-1-quinolin-3-ylspiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-1′-{[3-(trifluoromethyl)pyridin-2-yl]methyl}spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-(4-pyridin-4-ylphenyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-(4-pyridin-2-ylphenyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(3′-fluorobiphenyl-4-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

(2-{[2-oxo-1-(4-pyridin-4-ylphenyl)-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl]methyl}-1H- imidazol-1-yl)acetic acid;

1-(4′-methylbiphenyl-4-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

2-{[2-oxo-1-(4-pyridin-4-ylphenyl)-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl]methyl}nicotinic acid;

1′-[(3-methylpyridin-2-yl)methyl]-1-[4-(2-thienyl)phenyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-[4-(3-thienyl)phenyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(9H-fluoren-2-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-(9-oxo-9H-fluoren-2-yl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-(1H-imidazol-2-ylmethyl)-1-(4-pyridin-4-ylphenyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

2-[(1-biphenyl-4-yl-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl)methyl]nicotinamide;

2-(2-{[2-oxo-1-(4-pyridin-4-ylphenyl)-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl]methyl}-1H-imidazol-1-yl)propanoic acid;

3-(2-{[2-oxo-1-(4-pyridin-4-ylphenyl)-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl]methyl}-1H-imidazol-1-yl)prop anoic acid;

2-(2-{[2-oxo-1-(4-pyridin-4-ylphenyl)-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl]methyl}-1H-imidazol-1-yl)acetamide;

1′-[(3-methylpyridin-2-yl)methyl]-1-(5-phenyl-2-thienyl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-(2-phenyl-1,3-thiazol-4-yl)spiro[indole-3,4′-piperidin]-2(1H)-one;

1-(4-methyl-2-phenyl-1,3-thiazol-5-yl)-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1′-[(3-methylpyridin-2-yl)methyl]-1-[4-(3-methylpyridin-4-yl)phenyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-[4-(3-methylpyridin-4-yl)cyclohexyl]-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-6-bromo-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-4-bromo-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-7-bromo-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-6-fluoro-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-6-methyl-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-4-methyl-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-6-cyano-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

1-biphenyl-4-yl-4-cyano-1′-[(3-methylpyridin-2-yl)methyl]spiro[indole-3,4′-piperidin]-2(1H)-one;

(1-biphenyl-4-yl-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl)acetic acid

1-biphenyl-4-yl-1′-(carboxymethyl)-2-oxo-1,2-dihydrospiro[indole-3,4′-piperidine]-2′-carboxylic acid;

{2-[(1-biphenyl-4-yl-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl)methyl]pyridin-3-yl}acetic acid;

methyl [1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl](hydroxy)acetate;

1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidine]-2′-carboxylic acid;

1-biphenyl-4-yl-1′-(carboxymethyl)-2-oxo-1,2-dihydrospiro[indole-3,4′-piperidine]-2′-carboxylic acid;

[1-biphenyl-4-yl-2-oxo-2′-(pyridin-2-ylcarbonyl)-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl]acetic acid;

{1-biphenyl-4-yl-2′-[hydroxy(pyridin-2-yl)methyl]-2-oxo-1,2-dihydro-1′H-spiro[indole-3,4′-piperidin]-1′-yl}acetic acid;

[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl](hydroxy)acetic acid;

[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl](hydroxy)acetic acid;

[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl](hydroxy)acetic acid;

[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl](hydroxy)acetic acid;

[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl](hydroxy)acetic acid;

2-[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl]-2-hydroxyacetamide;

2-[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl]-2-hydroxyacetamide;

2-[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl]-2-hydroxy-N-isopropylacetamide ;

N-[[1-biphenyl-4-yl-2-oxo-1′-(pyridin-2-ylmethyl)-1,2-dihydrospiro[indole-3,4′-piperidin]-2′-yl](hydroxy)acetyl]glycine;

or a pharmaceutically acceptable salt thereof.