2-acylaminothiazole derivative or salt thereof
A 2-acylaminothiazole derivative or a pharmaceutically acceptable salt thereof having an excellent effect of proliferating human c-mpl-Ba/F3 cells and an activity of increasing platelets based on the effect of promoting the formation of megakaryocytic colonies. A compound or a pharmaceutically acceptable salt thereof useful in treating thrombocytopenia.
1. A method for the treatment of idiopathic thrombocytopenia purpura in a subject in need thereof, the method comprising:
administering to a subject in need thereof therapeutically effective amount of a compound selected from the group consisting of:
and pharmaceutically acceptable salts thereof,
wherein idiopathic thrombocytopenia purpura in the subject is treated.
2. The method according to claim 1 , wherein the compound is:
3. The method according to claim 1 or 2 , wherein the method comprises: administering the compound in a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier.
4. The method according to claim 3 , wherein the pharmaceutical composition is formulated for oral administration.
5. The method according to claim 4 , wherein the effective amount of the compound is a daily dosage of between about 0.01 and about 1 mg/kg.
6. The method according to claim 5 , wherein the method comprises:
administering the effective amount of the compound in the form of one or more tablets once daily.
7. The method according to claim 3 , wherein the method comprises:
administering the therapeutically effective amount of the compound to the subject having a depressed platelet level, wherein the platelet level in the subject is increased or recovered.
8. The method according to claim 1 or 2 , wherein the method comprises: administering the therapeutically effective amount of the compound to the subject such that administration results in cell proliferation and production of mature megakaryocytes and platelets.