IP Library › Granted Patent US 8,288,547
Granted Patent B2
US 8,288,547 · App. 12/625,649 · Granted Oct 16, 2012

N-methylnaltrexone zwitterion

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Quick Facts
Patent No.
US 8,288,547
App. No.
12/625,649
Granted
Oct 16, 2012
Kind
B2
Abstract

The invention discloses and claims N-Methylnaltrexone zwitterion, of formula (I), substantially in the anhydrous form or a hydrate thereof:

Claims (10)

1. N-Methylnaltrexone zwitterion, of formula (I), substantially in the anhydrous form or a hydrate thereof:

2. N-methylnaltrexone zwitterion according to claim 1 , which is in the (R) configuration relative to the nitrogen atom.

3. N-methylnaltrexone zwitterion according to claim 1 , which is in the (S) configuration relative to the nitrogen atom.

4. N-methylnaltrexone zwitterion according to claim 1 , which is in the form of a hydrate chosen from hemihydrate, dihydrate or trihydrate.

5. N-methylnaltrexone zwitterion according to claim 2 , which is in the form of a hydrate chosen from hemihydrate, dihydrate or trihydrate.

6. N-methylnaltrexone zwitterion according to claim 3 , which is in the form of a hydrate chosen from hemihydrate, dihydrate or trihydrate.

7. (R)—N-methylnaltrexone zwitterion, dihydrate.

8. O-Benzyl-N-methylnaltrexone methyl sulfate.

9. O-Benzyl-N-methylnaltrexone methyl sulfate according to claim 8 in the (R) configuration relative to the nitrogen atom.

10. O-Benzyl-N-methylnaltrexone methyl sulfate according to claim 8 in the (S) configuration relative to the nitrogen atom.

Assignments (2)
CHANGE OF NAME Recorded Jun 20, 2012
From: SANOFI-AVENTIS
To: SANOFI
Reel/Frame 028413/0927 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 13, 2010
From: DLUBALA, ALAIN
To: SANOFI-AVENTIS
Reel/Frame 024222/0729 →