ErbB interface peptidomimetics and methods of use thereof
View Patent ↗Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
1. An isolated peptide having an amino acid sequence of Y-C-P-I-W-K-F-P-D-E-E-C-Y (SEQ ID NO: 31); Y-C-L-V-W-K-Y-A-D-A-G-C-Y (SEQ ID NO: 32); Y-C-P-I-Y-K-Y-P-D-V-Q-C-Y (SEQ ID NO: 33); or Y-C-F-I-F-K-Y-A-D-P-D-C-Y (SEQ ID NO: 34).
2. The isolated peptide according to claim 1 having an amino acid sequence of Y-C-P-I-W-K-F-P-D-E-E-C-Y (SEQ ID NO: 31).
3. The isolated peptide according to claim 1 having an amino acid sequence of Y-C-L-V-W-K-Y-A-D-A-G-C-Y (SEQ ID NO: 32).
4. The isolated peptide according to claim 1 having an amino acid sequence of Y-C-P-I-Y-K-Y-P-D-V-Q-C-Y (SEQ ID NO: 33).
5. The isolated peptide according to claim 1 having an amino acid sequence of Y-C-F-I-F-K-Y-A-D-P-D-C-Y (SEQ ID NO: 34).