Coatings with tunable solubility profile for drug-coated balloon
A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, and a second therapeutic agent and a second excipient. The first and second therapeutic agents have different dissolution rates during balloon inflation and therefore provide a coating that is tunable.
1. A balloon for delivery of a drug, the balloon comprising
a body having an outer surface; and
a coating disposed on at least a length of the outer surface, the coating including zotarolimus and at least one excipient, wherein the zotarolimus to excipient weight ratio is from about 20:1 to about 1:20, wherein the at least one excipient includes polyvinylpyrrolidone, and further wherein the at least one excipient increases the solubility of the zotarolimus to between 4 μg/ml to 1437 μg/ml.
2. The balloon of claim 1 , wherein the zotarolimus to excipient weight ratio is from about 2:1 to about 1:2.
3. The balloon of claim 1 , wherein the coating further includes a plasticizer.
4. The balloon of claim 3 , wherein the excipient to plasticizer weight ratio is from about 20:1 to about 1:20.
5. The balloon of claim 4 , wherein the excipient to plasticizer weight ratio is from about 10:1 to about 1:1.
6. The balloon of claim 3 , wherein the plasticizer is glycerol.
7. The balloon of claim 1 , wherein the at least one excipient includes a blend of polyvinylpyrrolidone having two different average molecular weights.
8. The balloon of claim 1 , wherein the at least one excipient is blended with a contrast agent.
9. The balloon of claim 1 , wherein the at least one excipient includes a polymer having a molecular weight of less than about 35 kDalton.
10. The balloon of claim 1 , further comprising a second excipient, wherein the second excipient is a polymer having a molecular weight greater than about 100 kDalton.