Pyridine derivatives and their use in the treatment of psychotic disorders
A pyridine derivative novel compounds of formula (I) or a pharmaceutically acceptable salt thereof where all variables are defined herein. The compounds are useful in the treatment of psychotic disorders.
1. A method of treatment of alcohol dependence which comprises administering to a human in need thereof an effective amount of a compound of formula
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the compound is 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide.
3. The method of claim 1 , wherein the compound is 2-[3,5-Bis(trifluoromethyl)phenyl]-N-{4-(4-fluoro-2-methylphenyl)-6-[(7S,9aS)-7-(hydroxymethyl)hexahydropyrazino[2,1-c][1,4]oxazin-8(1H)-yl]-3-pyridinyl}-N,2-dimethylpropanamide hydrochloride.
4. The method of claim 1 , wherein the compound is administered together with a pharmaceutically acceptable carrier or excipient.
5. The method of claim 2 , wherein the compound is administered together with a pharmaceutically acceptable carrier or excipient.
6. The method of claim 3 , wherein the compound is administered together with a pharmaceutically acceptable carrier or excipient.