Macrolactone derivatives

1. A compound of the formula (I):

wherein:

X and Y independently of one another are OH, O—(C 1 -C 6 )-alkyl, NH 2 or NH—(C 1 -C 6 )-alkyl, or X and Y together form a group —O—;

R1 and R2 independently of one another are Cl or H;

R3 is H, (C 1 -C 6 )-alkyl, C(═O)—(C 1 -C 6 )-alkyl or (C 1 -C 6 )-alkylene-NH—(C 1 -C 6 )-alkyl; and

R4 is H, (C 1 -C 6 )-alkyl or C(═O)—(C 1 -C 6 )-alkyl;

or a physiologically acceptable salt of the compound of the formula (I).

2. The compound of formula (I) according to claim 1 , wherein X and Y together form a group —O—.

3. The compound of formula (I) according to claim 1 , wherein R3 and R4 independently of one another are H, (C 1 -C 6 )-alkyl or C(═O)—(C 1 -C 6 )-alkyl.

4. The compound of formula (I) according to claim 2 , wherein R3 and R4 independently of one another are H, (C 1 -C 6 )-alkyl or C(═O)—(C 1 -C 6 )-alkyl.

5. The compound of formula (I) according to claim 1 , wherein R1 and R2 are equal to Cl.

6. The compound of formula (I) according to claim 2 , wherein R1 and R2 are equal to Cl.

7. The compound of formula (I) according to claim 3 , wherein R1 and R2 are equal to Cl.

8. The compound of formula (I) according to claim 4 , wherein R1 and R2 are equal to Cl.

9. The compound of formula (I) according to claim 1 , where R1 is equal to Cl and R2 is equal to H.

10. The compound of formula (I) according to claim 2 , where R1 is equal to Cl and R2 is equal to H.

11. The compound of formula (I) according to claim 3 , where R1 is equal to Cl and R2 is equal to H.

12. The compound of formula (I) according to claim 4 , where R1 is equal to Cl and R2 is equal to H.

13. The compound of the formula (I) according to claim 1 , wherein R3 and R4 are equal to H.

14. The compound of the formula (I) according to claim 2 , wherein R3 and R4 are equal to H.

15. The compound of formula (I) according to claim 1 , where R1, R2, R3 and R4 are equal to H.

16. The compound of the formula (I) according to claim 2 , where R1, R2, R3 and R4 are equal to H.

17. A medicament comprising a compound of formula (I) according to claim 1 , or a physiologically acceptable salt thereof, and one or more pharmacologically suitable excipients.

18. A method for the treatment of a fungal disorder, comprising administering to a patient in need thereof an effective amount of a compound of formula (1) according to claim 1 , or a physiologically acceptable salt thereof.

19. A process for the preparation of a compound of the formula (I),

wherein:

X and Y independently of one another are OH, O—(C 1 -C 6 )-alkyl, NH 2 or NH—(C 1 -C 6 )-alkyl, or X and Y together form a group —O—;

R1 and R2 independently of one another are Cl or H;

R3 is H, (C 1 -C 6 )-alkyl, C(═O)—(C 1 -C 6 )-alkyl or (C 1 -C 6 )-alkylene-NH—(C 1 -C 6 )-alkyl; and

R4 is H, (C 1 -C 6 )-alkyl or C(═O)—(C 1 -C 6 )-alkyl;

or a physiologically acceptable salt of the compound of the formula (I), comprising:

1) fermenting the strain ST 201196 (DSM 18870) or one of its variants and/or mutants under suitable conditions in a culture medium which contains a Cl source, until one or more of the compounds of formula (I) accumulates in the culture medium; and

2) isolating the compound of formula (I) from the culture medium; and

3) optionally derivatizing the compound of the formula (I) and/or converting it into a physiologically acceptable salt.

20. The process as claimed in claim 19 , where in the compound of formula (I), X and Y together form a group —O—, R1 and R2 independently of one another are Cl or H, and R3 and R4 independently of one another are H, (C 1 -C 6 )-alkyl or C(═O)—(C 1 -C 6 )-alkyl.

21. The microorganism strain ST 201196 (DSM 18870).

22. The compound of claim 1 selected from the Formulae II, III, IV, V, and VI:

or a physiologically tolerable salt of the compound of Formulae (II), (III), (IV), (V).