Topical Acyl Glutathione Psoriasis Compositions
Topical compositions to treat inflammatory skin conditions such as psoriasis comprise an effective amount of S-acyl glutathione derivative and a carrier. Methods for treating inflammatory skin conditions such as psoriasis comprise applying a composition containing S-acyl glutathione derivative in a dermatologically acceptable carrier to skin tissue. The acyl group is a saturated or unsaturated aliphatic C 12 -C 24 group, preferably an unsaturated C 16 -C 24 group, most preferably an unsaturated C 18 group. In particularly preferred embodiments, the acyl group is a linoleoyl group.
1 . A topical composition for treatment of inflammatory skin conditions, comprising:
an effective amount of S-acyl glutathione derivative of formula (I)
wherein R 1 consists of a saturated or unsaturated aliphatic C 12 -C 24 group and R 2 is a hydrogen, aliphatic or aromatic acyl group;
and a dermatologically acceptable carrier.
2 . The topical composition of claim 1 wherein R 1 is an unsaturated C 18 group.
3 . The topical composition of claim 2 wherein R 1 is a linoleoyl or oleoyl group.
4 . The topical composition of claim 1 comprising between 5% to 90% by weight of S-acyl glutathione derivative.
5 . The topical composition of claim 5 comprising between 20% to 50% by weight of S-acyl glutathione derivative.
6 . The topical composition of claim 1 comprising greater than 50% by weight of S-acyl glutathione derivative.
7 . The topical composition of claim 1 wherein the carrier comprises lecithin.
8 . The topical composition of claim 1 further comprises lipoic acid.
9 . A topical composition for treatment of inflammatory skin conditions, comprising:
an effective amount of S-acyl glutathione derivative of formula (I)
wherein R 1 consists of a R 1 is a linoleoyl group and R 2 is a hydrogen, aliphatic or aromatic acyl group;
and a dermatologically acceptable carrier.
10 . The topical composition of claim 9 comprising between 5% to 90% by weight of S-acyl glutathione derivative.
11 . The topical composition of claim 9 comprising between 20% to 50% by weight of S-acyl glutathione derivative.
12 . The topical composition of claim 9 comprising greater than 50% by weight of S-acyl glutathione derivative.
13 . The topical composition of claim 9 wherein the carrier comprises lecithin.
14 . The topical composition of claim 9 further comprising lipoic acid.
15 . A method for the treatment of inflammatory skin conditions comprising:
applying a composition containing S-acyl glutathione derivative of formula (I):
wherein R 1 consists of a saturated or unsaturated aliphatic C 12 -C 24 group and R 2 is a hydrogen, aliphatic or aromatic acyl group; and a dermatologically acceptable carrier; to skin tissue.
16 . The method of claim 15 wherein R 1 is an unsaturated C 18 group.
17 . The method of claim 16 wherein R 1 is a linoleoyl or oleoyl group.
18 . The method of claim 15 comprising between 5% to 90% by weight of S-acyl glutathione derivative.
19 . The method of claim 18 comprising between 20% to 50% by weight of S-acyl glutathione derivative.
20 . The method of claim 15 comprising greater than 50% by weight of S-acyl glutathione.
21 . The method of claim 15 wherein the inflammatory skin condition is psoriasis.
22 . The method of claim 15 wherein said composition further comprises lipoic acid.
23 . A method for the treatment of inflammatory skin conditions, comprising:
applying a composition containing S-linoleoyl glutathione in a dermatologically acceptable carrier to skin tissue.
24 . The method of claim 23 comprising between 5% to 90% by weight of S-linoleoyl glutathione.
25 . The method of claim 24 comprising between 20% to 90% by weight of S-linoleoyl glutathione.
26 . The method of claim 23 comprising greater than 50% by weight of S-linoleoyl glutathione.
27 . The method of claim 23 wherein the inflammatory skin condition is psoriasis.
28 . The method of claim 23 wherein said composition further comprises lipoic acid.