Small molecule Bcl-Xl/Bcl-2 binding inhibitors
View Patent ↗Bcl-xL/Bcl-2 binding inhibitors useful in the treatment of unwanted proliferating cells, including cancers and precancers, in subjects in need of such treatment. Also provided are methods of treating a subject having unwanted proliferating cells comprising administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject in need of such treatment. Also provided are methods of preventing the proliferation of unwanted proliferating cells, such as cancers and precancers, in a subject comprising the step of administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject at risk of developing a condition characterized by unwanted proliferating cells.
1. A method of treating prostate cancer, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula III
wherein X 1 is H, alkyl, alkoxy, halo, nitro, haloalkylaryl, haloaryl, alkylaryl, and combinations thereof; and
X 2 is alkyl other than methyl, alkoxy other than methyl, halo other than bromo, and combinations thereof;
and pharmaceutically acceptable salts thereof.
2. The method according to claim 1 , wherein the compound is administered orally, intravenously, intramuscularly, subcutaneously, or intraperitoneally.
3. The method according to claim 2 , wherein the therapeutically effective amount administered is in the range of about 0.1-2000 mg.
4. The method according to claim 2 , wherein the therapeutically effective amount administered is in the range of about 1-200 mg per kg of body weight of the subject.