Peptides that home to tumor lymphatic vasculature and methods of using same
View Patent ↗The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering to the subject a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature.
1. An isolated peptidomimetic, said peptidomimetic comprising the amino acid sequence GNKRTRG (SEQ ID NO: 2), wherein the peptidomimetic selectively homes to lymphatic vasculature of a tumor.
2. The isolated peptidomimetic of claim 1 , which is conformationally constrained.
3. The isolated peptidomimetic of claim 1 , which is cyclic.
4. A conjugate, comprising a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature, wherein said homing molecule comprises the peptidomimetic of claim 1 .
5. The conjugate of claim 4 , which wherein the peptidomimetic is conformationally constrained.
6. The conjugate of claim 4 , which wherein the peptidomimetic is cyclic.
7. An isolated peptidomimetic, said peptidomimetic comprising the amino acid sequence CGNKRTRGC (SEQ ID NO: 1), wherein the peptidomimetic selectively homes to lymphatic vasculature of a tumor.
8. The isolated peptidomimetic of claim 7 , which is conformationally constrained.
9. The isolated peptidomimetic of claim 7 , which is cyclic.
10. A conjugate, comprising a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature, wherein said homing molecule comprises the peptidomimetic of claim 7 .
11. The conjugate of claim 10 , wherein the peptidomimetic is conformationally constrained.
12. The conjugate of claim 10 , wherein the peptidomimetic is cyclic.