IP Library › Granted Patent US 8,822,661
Granted Patent B2
US 8,822,661 · App. 12/667,269 · Granted Sep 2, 2014

Xylose reductase mutants and uses thereof

Inventors: Huimin Zhao (Champaign, IL); Nikhil Unni Nair (Urbana, IL)
Assignees: The Board of Trustees of the University of Illinois; Biotechnology Research and Development Corporation
C12N9/0006
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Quick Facts
Patent No.
US 8,822,661
App. No.
12/667,269
Granted
Sep 2, 2014
Kind
B2
Abstract

Engineered mutant xylose reductases demonstrate higher preference to xylose than arabinose. Amino acid mutations were engineered in to native xylose reductase from Neurospora crassa . Mutant xylose reductases are useful in the production of xylitol and ethanol.

Claims (1)

1. An engineered nucleic acid molecule comprising a sequence encoding a mutant xylose reductase that has the amino acid sequence of SEQ ID NO:1 with an amino acid substitution of L109Q.

Assignments (1)
SECURITY AGREEMENT Recorded Apr 4, 2013
From: ZUCHEM, INC.
To: 2120 INVESTMENTS, INC.
Reel/Frame 030156/0134 →
Continuity (2)
Provisional Application 60949387 · Jul 12, 2007
Related Publication 20100291645A1 · Nov 18, 2010